Sabzghabaee Ali Mohammad, Kelishadi Roya, Jelokhanian Hadi, Asgary Sedigheh, Ghannadi Alireza, Badri Shirinsadat
Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Med Arch. 2014 Jun;68(3):195-9. doi: 10.5455/medarh.2014.68.195-199. Epub 2014 May 31.
Childhood obesity is a major public health concern worldwide while the current epidemic may be secondary to over consumption of high-fat, energy-rich foods. Purslane (Portulaca oleracea L.) has been traditionally used in medicine for several antioxidant and anti-atherogenic activities. In this study the anti-dyslipidemic effects of P.oleracea was evaluated in obese adolescents.
In this triple-blinded randomized placebo-controlled clinical trial which was done from July 2011 to June 2012, obese adolescent patients whom were referred to the Isfahan Cardiovascular Research Institute (Iran) were randomly allocated to the two arms of cases and controls. The cases group was asked to take one capsule containing powdered P. oleracea seeds (500 milligrams) two times a day for one month, and the controls group were asked to take identical but placebo (lactose) capsules in the same way. Biochemical parameters including 12-hours fasting serum levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were measured before the initiation and after the completion of the study protocol.
Total cholesterol, LDL-C, and TG showed statistically significant changes over time (one month) in the P. oleracea group (p < 0.05). However, between-group analysis using general linear model (multivariate) test revealed that the differences in the mentioned parameters between two study groups were statistically significant just for LDL-C and TG, while others did not differ significantly.
P. oleracea L. may have positive effects on serum lipids profile which may be attributed to its polyphenolic and antioxidant compounds. This herbal drug seems to be well-tolerated in adolescent population as well. Further studies are recommended.
儿童肥胖是全球主要的公共卫生问题，当前的肥胖流行可能继发于高脂肪、高能量食物的过度摄入。马齿苋（Portulaca oleracea L.）传统上就因其多种抗氧化和抗动脉粥样硬化活性而用于医学。本研究评估了马齿苋对肥胖青少年的抗血脂异常作用。
在这项于2011年7月至2012年6月进行的三盲随机安慰剂对照临床试验中，被转诊至伊斯法罕心血管研究所（伊朗）的肥胖青少年患者被随机分为病例组和对照组。病例组被要求每天服用两粒含马齿苋种子粉末（500毫克）的胶囊，持续一个月，对照组则被要求以相同方式服用外观相同但为安慰剂（乳糖）的胶囊。在研究方案开始前和结束后测量包括12小时空腹血清总胆固醇、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）在内的生化参数。
马齿苋组的总胆固醇、LDL-C和TG在一个月的时间内显示出具有统计学意义的变化（p < 0.05）。然而，使用一般线性模型（多变量）检验进行的组间分析显示，两个研究组之间上述参数的差异仅在LDL-C和TG方面具有统计学意义，而其他参数无显著差异。
马齿苋可能对血脂谱有积极影响，这可能归因于其多酚和抗氧化化合物。这种草药在青少年人群中似乎也具有良好的耐受性。建议进一步开展研究。
