Turusov V S
Vopr Onkol. 1989;35(10):1214-9.
16 spontaneous tumors of the peripheral nerves and 18 spontaneous tumors of mesenchymal origin in BDVI rats were studied by peroxidase-antiperoxidase method using anti-serum (DAKOPATT) against protein S-100. The majority of spontaneous peripheral nerve tumors were of cystic histological structure identical to that of cystic neurinomas induced in rats by ethylnitrosourea and almost all of these tumors were S-100 protein positive. The incidence of spontaneous neurinomas in BDVI rats was in some experiments as high as 5%. All tumors of mesenchymal origin (except one lipoma) were S-100 protein negative: 2 fibromas, 6 fibrosarcomas, 3 malignant fibrous histiocytomas, one rhabdomyosarcoma and one hemangioendothelioma. S-100 protein is found, as in human pathology, useful for distinguishing tumors of schwann cell and mesenchymal origin in rats.
采用抗蛋白S - 100抗血清（DAKOPATT），通过过氧化物酶 - 抗过氧化物酶法对BDVI大鼠的16例自发性周围神经肿瘤和18例间充质起源的自发性肿瘤进行了研究。大多数自发性周围神经肿瘤具有与乙基亚硝基脲诱导的大鼠囊性神经鞘瘤相同的囊性组织结构，并且几乎所有这些肿瘤的S - 100蛋白均呈阳性。在某些实验中，BDVI大鼠自发性神经鞘瘤的发生率高达5%。所有间充质起源的肿瘤（除1例脂肪瘤外）S - 100蛋白均为阴性：2例纤维瘤、6例纤维肉瘤、3例恶性纤维组织细胞瘤、1例横纹肌肉瘤和1例血管内皮瘤。正如在人类病理学中一样，发现S - 100蛋白有助于区分大鼠雪旺细胞起源和间充质起源的肿瘤。
