Turusov V S
Arkh Patol. 1994 Jan-Feb;56(1):50-5.
Twenty-seven peripheral nerve tumours of BD VI rats from the histological archives of the International Agency for Research on Cancer were immunohistochemically studied for GFAP reactivity. Twelve tumours were induced by nitrosoethylurea (NEU) and 13 tumours were spontaneous. Thirteen tumours (7 of them NEU-induced and 6 spontaneous) revealed GFAP-reactivity which was relatively high (large areas of GFAP-positive cells) in 4 neoplasms (3 induced and 1 spontaneous). GFAP-positive tumours were not histologically distinguishable from GFAP-negative tumours. GFAP-positive tumours were also positive for S-100 protein although the incidence and the intensity of GFAP-reactivity were much lower than that of S-100 reactivity. Early NEU-induced schwannomas were negative for GFAP and S-100; all GFAP-and S-100-positive tumours were large neoplasms with an invasive growth. GFAP-positivity was observed in both solid and cystic schwannomas. The results of the study represent the additional data on the observation of GFAP outside of the central nervous system.
对国际癌症研究机构组织学档案中27只BD VI大鼠的周围神经肿瘤进行免疫组织化学研究，以检测其胶质纤维酸性蛋白（GFAP）反应性。12只肿瘤由亚硝基乙基脲（NEU）诱发，13只肿瘤为自发形成。13只肿瘤（其中7只为NEU诱发，6只为自发形成）显示出GFAP反应性，4例肿瘤（3例诱发和1例自发）中GFAP反应性相对较高（GFAP阳性细胞面积较大）。GFAP阳性肿瘤在组织学上与GFAP阴性肿瘤无法区分。GFAP阳性肿瘤的S-100蛋白也呈阳性，尽管GFAP反应性的发生率和强度远低于S-100反应性。早期NEU诱发的神经鞘瘤GFAP和S-100均为阴性；所有GFAP和S-100阳性肿瘤均为具有侵袭性生长的大肿瘤。在实性和囊性神经鞘瘤中均观察到GFAP阳性。该研究结果为中枢神经系统外GFAP的观察提供了更多数据。
