Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Shinjuku-ku, Tokyo 162-8480, Japan.
School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Int J Mol Sci. 2020 Mar 10;21(5):1884. doi: 10.3390/ijms21051884.
The circadian clock system works not only as a cellular time-keeper but also as a coordinator for almost all physiological functions essential to maintaining human health. Therefore, disruptions or malfunctions of this system can cause many diseases and pre-symptomatic conditions. Indeed, previous studies have indicated that disrupted clock gene expression rhythm is closely related to obesity, and that allergic diseases can be regulated by controlling peripheral clocks in organs and tissues. Moreover, recent studies have found that obesity can lead to immune disorders. Accordingly, in this review, we assess the connection between obesity and allergy from the point of view of the circadian clock system anew and summarize the relationships among the circadian clock system, obesity, and allergy.
生物钟系统不仅作为细胞的计时器，而且作为协调人体健康所必需的几乎所有生理功能的协调者。因此，该系统的中断或故障会导致许多疾病和症状前状况。事实上，先前的研究表明，时钟基因表达节律的紊乱与肥胖密切相关，过敏疾病可以通过控制器官和组织中的外周时钟来调节。此外，最近的研究发现肥胖可导致免疫紊乱。因此，在这篇综述中，我们从生物钟系统的角度重新评估肥胖与过敏之间的关系，并总结生物钟系统、肥胖和过敏之间的关系。
