Walecka-Kapica Ewa, Klupińska Grażyna, Chojnacki Jan, Tomaszewska-Warda Karolina, Błońska Aleksandra, Chojnacki Cezary
Department of Clinical Nutrition and Gastroenterological Diagnostic, Medical University of Lodz, Poland.
Department of Gastroenterology, Medical University of Lodz, Poland.
Prz Menopauzalny. 2014 Dec;13(6):334-8. doi: 10.5114/pm.2014.47986. Epub 2014 Dec 30.
We evaluated the effect of melatonin supplementation on the nutritional status of postmenopausal women.
The study included 56 women (51-65 years) and 25 healthy women (27-36 years). The emotional state was assessed using Hamilton Depression Rating Scale (HAM-D), the quality of sleep using Insomnia Severity Index (ISI). Body mass index (BMI) and waist-hip ratio (WHR) were also calculated. The patients were divided into 3 groups: group I (control) - 25 women with normal body weight, group II - 26 postmenopausal women with normal body weight, group III - 30 postmenopausal women with high body weight. In women from group II and III, routine laboratory tests, levels of thyroid-stimulating hormone (TSH), 17β-estradiol, prolactin, follicle-stimulating hormone (FSH) and the concentration of 6-hydroxymelatonin sulphate (6-HMS) in day/night urine fractions were determined. On the day of the examination, women remained on a liquid diet (1800 kcal). Next, a balanced diet of 1500 kcal and 5 mg of melatonin administration were recommended. The follow-up examinations were performed after 4, 8, 12, 16, 20 and 24 weeks.
The patients from groups II and III showed similar mild levels of anxiety and depression and a significant degree of sleep disorders. In group III, lower urinary 6-HMS excretion was observed at night. In both groups a negative correlation was found between urinary 6-HMS excretion and the degree of sleep disorders. After 24 weeks, a statistically significant improvement of quality of sleep was obtained. A negative correlation was detected between urinary 6-HMS excretion and BMI.
Melatonin supplementation contributed to body weight reduction.
我们评估了补充褪黑素对绝经后女性营养状况的影响。
该研究纳入了56名年龄在51 - 65岁的女性以及25名年龄在27 - 36岁的健康女性。使用汉密尔顿抑郁量表（HAM - D）评估情绪状态，使用失眠严重程度指数（ISI）评估睡眠质量。还计算了体重指数（BMI）和腰臀比（WHR）。患者被分为3组：第一组（对照组）——25名体重正常的女性，第二组——26名体重正常的绝经后女性，第三组——30名体重超重的绝经后女性。对第二组和第三组的女性进行了常规实验室检查，测定了促甲状腺激素（TSH）、17β - 雌二醇、催乳素、卵泡刺激素（FSH）水平以及日/夜尿样中硫酸6 - 羟基褪黑素（6 - HMS）的浓度。在检查当天，女性保持流食（1800千卡）。接下来，建议采用1500千卡的均衡饮食并服用5毫克褪黑素。在4、8、12、16、20和24周后进行随访检查。
第二组和第三组的患者表现出相似的轻度焦虑和抑郁水平以及显著程度的睡眠障碍。在第三组中，夜间尿中6 - HMS排泄量较低。两组中均发现尿中6 - HMS排泄量与睡眠障碍程度之间呈负相关。24周后，睡眠质量得到了统计学上的显著改善。尿中6 - HMS排泄量与BMI之间存在负相关。
补充褪黑素有助于减轻体重。
