Dias Renata de Oliveira, Machado Leandro Dos Santos, Migliolo Ludovico, Franco Octavio Luiz
SInova, Programa de Pós Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil.
Molecules. 2015 Jan 5;20(1):519-41. doi: 10.3390/molecules20010519.
Lectins are multivalent proteins with the ability to recognize and bind diverse carbohydrate structures. The glyco -binding and diverse molecular structures observed in these protein classes make them a large and heterogeneous group with a wide range of biological activities in microorganisms, animals and plants. Lectins from plants and animals are commonly used in direct defense against pathogens and in immune regulation. This review focuses on sources of animal and plant lectins, describing their functional classification and tridimensional structures, relating these properties with biotechnological purposes, including antimicrobial activities. In summary, this work focuses on structural-functional elucidation of diverse lectin groups, shedding some light on host-pathogen interactions; it also examines their emergence as biotechnological tools through gene manipulation and development of new drugs.
凝集素是具有识别和结合多种碳水化合物结构能力的多价蛋白质。在这些蛋白质类别中观察到的糖结合和多样的分子结构，使它们成为一个庞大且异质的群体，在微生物、动物和植物中具有广泛的生物活性。来自植物和动物的凝集素通常用于直接抵御病原体和免疫调节。本综述重点关注动植物凝集素的来源，描述它们的功能分类和三维结构，并将这些特性与生物技术用途（包括抗菌活性）相关联。总之，这项工作侧重于阐明不同凝集素群体的结构功能，为宿主-病原体相互作用提供一些启示；它还研究了通过基因操作和新药开发，它们作为生物技术工具的出现。
