Department of Psychiatry and Behavioural Neurosciences, McMaster University, Canada; Department of Pediatrics, McMaster University, Canada; Department of Clinical Epidemiology and Biostatistics, McMaster University, Canada; Offord Centre for Child Studies, McMaster University, Canada; CanChild Centre for Childhood Disability Research, McMaster University, Canada.
Department of Pediatrics, McMaster University, Canada; CanChild Centre for Childhood Disability Research, McMaster University, Canada.
J Affect Disord. 2015 Mar 15;174:594-601. doi: 10.1016/j.jad.2014.12.014. Epub 2014 Dec 26.
Little is known about the natural course of depressive symptoms among youth with chronic illness during their transition from adolescence to young adulthood.
A representative epidemiological sample of 2825 youth aged 10-11 years from the National Longitudinal Survey of Children and Youth were followed until 24-25 years of age. Presence of chronic illness was measured using self-report and symptoms of depression were assessed using the Center for Epidemiological Studies Depression Scale. Multilevel modeling was used to investigate trajectories of depressive symptoms, adjusting for family environment and sociodemographic characteristics during the transition to young adulthood.
Trajectories showed cubic change over time - increasing from early to mid-adolescence, decreasing to early young adulthood, increasing again to late young adulthood. Youth with chronic illness (n=753) had significantly less favorable trajectories and significantly higher proportions of clinically relevant depressive symptoms over time compared to their peers without chronic illness (n=2072).
This study is limited by selective attrition, self-reported chronic illness and no assessment of illness severity, and mediating effects of family environment factors could not be examined.
Findings support the diathesis-stress model; chronic illness negatively influenced depressive symptoms trajectories, such that youth with chronic illness had higher depression scores and less favorable trajectories over time. The health and school system are uniquely positioned to support youth with chronic illness navigate this developmental period in an effort to prevent declines in mental health.
青少年在从青春期过渡到青年期的过程中,患有慢性病的青年的抑郁症状的自然病程知之甚少。
对来自全国儿童纵向研究的 2825 名年龄在 10-11 岁的代表性流行病学样本进行了随访,直至他们 24-25 岁。使用自我报告来衡量慢性病的存在,使用流行病学研究中心抑郁量表来评估抑郁症状。使用多层次模型来调查抑郁症状的轨迹,同时调整了青年期过渡期间的家庭环境和社会人口特征。
轨迹显示时间上的三次变化——从中年早期到中期增加,到早期青年期减少,再到晚期青年期增加。患有慢性病的青年(n=753)与没有慢性病的同龄人(n=2072)相比,轨迹明显不太有利,且随着时间的推移,具有临床相关抑郁症状的比例明显更高。
本研究受到选择性流失、自我报告的慢性病和未评估疾病严重程度的限制,并且无法检查家庭环境因素的中介效应。
研究结果支持素质-应激模型;慢性病对抑郁症状轨迹有负面影响,即患有慢性病的青年随着时间的推移,抑郁评分更高,轨迹更差。卫生和学校系统具有独特的地位,可以支持患有慢性病的青年在这一发展时期进行过渡,以防止心理健康状况恶化。