McCarthy Kayne, Ye Yong-ling, Yuan Shuai, He Qi-qiang
School of Public Health, Wuhan University, Wuhan, P. R. China and University of Hawaii Office of Public Health Studies, Honolulu, Hawaii.
School of Public Health, Wuhan University, Wuhan, P. R. China.
Prev Chronic Dis. 2015 Jan 8;12:E01. doi: 10.5888/pcd12.140384.
Prevalence of childhood obesity in China is increasing, and parental weight is a risk factor for the development of obesity in children. We examined the relationship of parental body weight status with risk of offspring cardiovascular disease (CVD) in Chinese children.
We conducted a cross-sectional study in Wuhan, China, during May and June 2010. Parental body mass index (BMI) was calculated according to self-reported height and weight. Offspring CVD risk factors, including BMI, waist circumference, blood pressure, fasting glucose, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, cardiorespiratory fitness (CRF), and metabolic risk score (MRS), were assessed through anthropometric measures, blood samples, and a CRF test. Multiple linear regression and analysis of covariance were used to examine the effects of maternal and paternal weight status on offspring CVD risks.
A total of 580 Chinese children (339 boys and 241 girls, mean [standard deviation] age, 9.6 [0.7] years) participated in the study. Maternal BMI was significantly associated with offspring elevated BMI (β = 0.134, P = .002), waist circumference (β = 0.253, P = .04), and decreased CRF (β = -0.134, P = .01). Paternal BMI was significantly associated with elevated offspring BMI (β = 0.161, P < .001), waist circumference (β = 0.404, P < .001), triglycerides (β = 0.017, P = .03), MRS (β = 0.084, P = .03), and decreased CRF (β = -0.174, P < .001). BMI (P < .001), waist circumference (P < .001), and MRS (P < .05) were positively associated with additional overweight/obese parents, whereas CRF was negatively associated (P < .001).
Parental weight status was significantly associated with increased risk of CVD in their children, and the association was stronger for paternal weight status.
中国儿童肥胖症的患病率正在上升，父母的体重是儿童肥胖症发展的一个风险因素。我们研究了中国儿童中父母体重状况与子代心血管疾病（CVD）风险之间的关系。
2010年5月至6月期间，我们在中国武汉进行了一项横断面研究。根据自我报告的身高和体重计算父母的体重指数（BMI）。通过人体测量、血液样本和心肺适能（CRF）测试评估子代CVD风险因素，包括BMI、腰围、血压、空腹血糖、甘油三酯、高密度脂蛋白（HDL）胆固醇、低密度脂蛋白（LDL）胆固醇、心肺适能（CRF）和代谢风险评分（MRS）。使用多元线性回归和协方差分析来检验母亲和父亲体重状况对子代CVD风险的影响。
共有580名中国儿童（339名男孩和241名女孩，平均[标准差]年龄为9.6[0.7]岁）参与了该研究。母亲的BMI与子代BMI升高（β = 0.134，P = 0.002）、腰围增加（β = 0.253，P = 0.04）以及CRF降低（β = -0.134，P = 0.01）显著相关。父亲的BMI与子代BMI升高（β = 0.161，P < 0.001）、腰围增加（β = 0.404，P < 0.001）、甘油三酯升高（β = 0.017，P = 0.03）、MRS升高（β = 0.084，P = 0.03）以及CRF降低（β = -0.174，P < 0.001）显著相关。BMI（P < 0.001）、腰围（P < 0.001）和MRS（P < 0.05）与父母额外的超重/肥胖呈正相关，而CRF呈负相关（P < 0.001）。
父母的体重状况与子代患CVD的风险显著相关，且这种关联在父亲体重状况方面更强。
