Syal Supriya, Ipser Jonathan, Terburg David, Solms Mark, Panksepp Jaak, Malcolm-Smith Susan, Bos Peter A, Montoya Estrella R, Stein Dan J, van Honk Jack
Department of Psychiatry University of Cape Town South Africa; Department of Psychology University of Toronto Canada.
Department of Psychiatry University of Cape Town South Africa.
Psychoneuroendocrinology. 2015 Mar;53:10-5. doi: 10.1016/j.psyneuen.2014.11.009. Epub 2014 Nov 16.
In rodents, there is abundant evidence for the involvement of the opioid system in the processing of reward cues, but this system has remained understudied in humans. In humans, the happy facial expression is a pivotal reward cue. Happy facial expressions activate the brain's reward system and are disregarded by subjects scoring high on depressive mood who are low in reward drive. We investigated whether a single 0.2mg administration of the mixed mu-opioid agonist/kappa-antagonist, buprenorphine, would influence short-term memory for happy, angry or fearful expressions relative to neutral faces. Healthy human subjects (n38) participated in a randomized placebo-controlled within-subject design, and performed an emotional face relocation task after administration of buprenorphine and placebo. We show that, compared to placebo, buprenorphine administration results in a significant improvement of memory for happy faces. Our data demonstrate that acute manipulation of the opioid system by buprenorphine increases short-term memory for social reward cues.
在啮齿动物中，有大量证据表明阿片类系统参与奖赏线索的处理，但该系统在人类中的研究仍较少。在人类中，快乐的面部表情是关键的奖赏线索。快乐的面部表情会激活大脑的奖赏系统，而奖赏驱动力较低、抑郁情绪得分高的受试者会忽视这些表情。我们研究了单次服用0.2毫克混合μ-阿片激动剂/κ-拮抗剂丁丙诺啡，相对于中性面孔，是否会影响对快乐、愤怒或恐惧表情的短期记忆。健康人类受试者（n = 38）参与了一项随机安慰剂对照的受试者内设计，并在服用丁丙诺啡和安慰剂后执行了一项情绪面孔重新定位任务。我们发现，与安慰剂相比，服用丁丙诺啡可显著改善对快乐面孔的记忆。我们的数据表明，丁丙诺啡对阿片类系统的急性调控可增强对社会奖赏线索的短期记忆。
