Telkes I, Ince N F, Onaran I, Abosch A
Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:2621-4. doi: 10.1109/EMBC.2014.6944160.
Deep brain stimulation of the subthalamic nucleus (STN) is a highly effective treatment for motor symptoms of Parkinson's disease. However, precise intraoperative localization of STN remains a procedural challenge. In the present study, local field potentials (LFPs) were recorded from DBS macroelectrodes during trajectory to STN, in six patients. The frequency-vs-depth map of LFP activity was extracted and further analyzed within different sub-bands, to investigate whether LFP activity can be used for STN border identification. STN borders identified by LFPs were compared to border predictions by the neurosurgeon, based on microelectrode-derived, single-unit recordings (MER-SUA). The results demonstrate difference between MER-SUA and macroelectrode LFP recording with respect to the dorsal STN border of -1.00 ±0.84 mm and -0.42 ±1.07 mm in the beta and gamma frequency bands, respectively. For these sub-bands, RMS of these distances was found to be 1.26 mm and 1.06 mm, respectively. Analysis of other sub-bands did not allow for distinguishing the caudal border of STN. In conclusion, macroelectrode-derived LFP recordings may provide an alternative approach to MER-SUA, for localizing the target STN borders during DBS surgery.
丘脑底核（STN）的深部脑刺激是帕金森病运动症状的一种高效治疗方法。然而，STN的精确术中定位仍然是一个操作上的挑战。在本研究中，对6例患者在向STN进针过程中从DBS宏电极记录局部场电位（LFP）。提取LFP活动的频率-深度图，并在不同子频段内进一步分析，以研究LFP活动是否可用于识别STN边界。将通过LFP识别的STN边界与神经外科医生基于微电极衍生的单单元记录（MER-SUA）做出的边界预测进行比较。结果表明，在β和γ频段，MER-SUA与宏电极LFP记录在STN背侧边界方面存在差异，分别为-1.00±0.84毫米和-0.42±1.07毫米。对于这些子频段，这些距离的均方根分别为1.26毫米和1.06毫米。对其他子频段的分析无法区分STN的尾侧边界。总之，宏电极衍生的LFP记录可能为MER-SUA提供一种替代方法，用于在DBS手术期间定位目标STN边界。
