Barnes Stephanie L, Whisenant Jennifer G, Yankeelov Thomas E
Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:4264-7. doi: 10.1109/EMBC.2014.6944566.
We first discuss several key technical issues associated with quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), and then provide examples of DCE-MRI in oncology. In particular, we examine the importance of both active and passive delivery of the contrast agent to the tissue under investigation, and repeatability/reproducibility in DCE-MRI studies. We then discuss examples of how DCE-MRI can assist in assessing and predicting therapeutic response in the neoadjuvant setting.
我们首先讨论与定量动态对比增强磁共振成像(DCE-MRI)相关的几个关键技术问题,然后给出DCE-MRI在肿瘤学中的应用实例。特别地,我们研究了造影剂主动和被动输送到被研究组织的重要性,以及DCE-MRI研究中的可重复性/再现性。接着,我们讨论DCE-MRI如何在新辅助治疗环境中协助评估和预测治疗反应的实例。