Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232-2675, USA.
Magn Reson Med. 2013 Jun;69(6):1721-34. doi: 10.1002/mrm.24422. Epub 2012 Jul 27.
Quantitative dynamic contrast enhanced magnetic resonance imaging estimates parameters related to tissue vascularity and volume fractions; additionally, semiquantitative parameters such as the initial area under the curve can be utilized to describe tissue behavior. The aim of this study was to establish the reproducibility of quantitative and semiquantitative analysis of dynamic contrast enhanced magnetic resonance imaging in a murine model of breast cancer. For each animal, a T1-weighted, gradient-echo sequence was used to acquire two sets of dynamic contrast enhanced magnetic resonance imaging data separated by 5 h. Data were acquired at both a 0.05 mm3 (128(2) , n=12) and a 0.2 mm3 (64(2), n=12) resolution, and analysis was performed using both the Tofts-Kety (to estimate Ktrans and ve) and extended Tofts-Kety (Ktrans, ve, and vp) models. Reproducibility analysis was performed for both the center slice and the total tumor volume for all parameters. For the total volume analysis, the repeatability index for Ktrans is 0.073 min(-1) in the standard model analysis and 0.075 min(-1) in the extended model analysis at the 128(2) acquisition. For the 64(2) acquisition, the values are 0.089 and 0.063 min(-1) for the standard and extended models, respectively. The repeatability index for initial area under the curve was 0.0039 and 0.0042 mM min for the 128(2) and 64(2) acquisitions, respectively.
定量动态对比增强磁共振成像估计与组织血管生成和体积分数相关的参数；此外，还可以利用半定量参数，如初始曲线下面积来描述组织行为。本研究旨在建立乳腺癌小鼠模型中定量和半定量动态对比增强磁共振成像分析的可重复性。对于每只动物，使用 T1 加权梯度回波序列采集两组间隔 5 小时的动态对比增强磁共振成像数据。在 0.05mm3（128(2)，n=12）和 0.2mm3（64(2)，n=12）分辨率下采集数据，并使用 Tofts-Kety（估计 Ktrans 和 ve）和扩展 Tofts-Kety（Ktrans、ve 和 vp）模型进行分析。对所有参数的中心切片和整个肿瘤体积进行了重复性分析。对于全容积分析，在标准模型分析中 Ktrans 的重复性指数在 128(2)采集时为 0.073 min(-1)，在扩展模型分析中为 0.075 min(-1)。对于 64(2)采集，标准和扩展模型的数值分别为 0.089 和 0.063 min(-1)。初始曲线下面积的重复性指数在 128(2)采集时为 0.0039，在 64(2)采集时为 0.0042 mM min。
