免疫功能及疫苗接种反应中的性别差异。
Sex-based differences in immune function and responses to vaccination.
作者信息
Klein Sabra L, Marriott Ian, Fish Eleanor N
机构信息
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Department of Biological Sciences, College of Liberal Arts & Sciences, University of North Carolina, Charlotte, North Carolina, USA.
出版信息
Trans R Soc Trop Med Hyg. 2015 Jan;109(1):9-15. doi: 10.1093/trstmh/tru167.
Females typically develop higher antibody responses and experience more adverse reactions following vaccination than males. These differences are observed in response to diverse vaccines, including the bacillus Calmette-Guerin vaccine, the measles, mumps and rubella vaccine, the yellow fever virus vaccine and influenza vaccines. Sex differences in the responses to vaccines are observed across diverse age groups, ranging from infants to aged individuals. Biological as well as behavioral differences between the sexes are likely to contribute to differences in the outcome of vaccination between the sexes. Immunological, hormonal, genetic and microbiota differences between males and females may also affect the outcome of vaccination. Identifying ways to reduce adverse reactions in females and increase immune responses in males will be necessary to adequately protect both sexes against infectious diseases.
女性通常比男性在接种疫苗后产生更高的抗体反应，并经历更多的不良反应。在对多种疫苗的反应中都观察到了这些差异，包括卡介苗、麻疹、腮腺炎和风疹疫苗、黄热病病毒疫苗和流感疫苗。在从婴儿到老年人的不同年龄组中都观察到了对疫苗反应的性别差异。两性之间的生物学以及行为差异可能导致两性接种疫苗结果的差异。男性和女性之间的免疫、激素、基因和微生物群差异也可能影响接种疫苗的结果。确定减少女性不良反应和增强男性免疫反应的方法对于充分保护两性免受传染病侵害至关重要。
Zotero 插件