半胱天冬酶在脂多糖上聚集。
Caspases come together over LPS.
作者信息
Smith Christina, Wang Xiaohui, Yin Hang
机构信息
Department of Chemistry & Biochemistry and the BioFrontiers Institute, University of Colorado Boulder, 596 UCB, Boulder, CO 80309-0596, USA.
Department of Chemistry & Biochemistry and the BioFrontiers Institute, University of Colorado Boulder, 596 UCB, Boulder, CO 80309-0596, USA; Chemical Biology Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
出版信息
Trends Immunol. 2015 Feb;36(2):59-61. doi: 10.1016/j.it.2014.12.007. Epub 2015 Jan 5.
Abstract
Caspases are cellular executors, initiating cell death. In a recent study, Shi et al. report that caspases 4/5/11 are cytosolic LPS receptors, becoming activated through oligomerization upon interaction with LPS. These findings shed new light on the mechanisms underlying caspase-mediated pyroptosis, and have implications for the development of effective drugs to treat sepsis.
摘要
半胱天冬酶是引发细胞死亡的细胞执行者。在最近的一项研究中，施等人报告称，半胱天冬酶4/5/11是胞质内脂多糖受体，与脂多糖相互作用时通过寡聚化被激活。这些发现为半胱天冬酶介导的细胞焦亡的潜在机制提供了新的线索，并对开发治疗败血症的有效药物具有启示意义。
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