Yi Eui-Yeun, Han Kyung-Suk, Kim Yung-Jin
Department of Molecular Biology, College of Natural Science, Pusan National University, Busan, Korea.
Biochem c.a.l.s., Ltd., Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea.
J Cancer Prev. 2014 Dec;19(4):247-52. doi: 10.15430/JCP.2014.19.4.247.
Angiogenesis is important processes for tumor growth and metastasis. Anti-angiogenesis target therapy has recently been known to be new anti-cancer therapeutic strategies. Natural products such as traditional medicine comprise a major source of angiogenesis inhibitors. Artemisia lavandulaefolia has been known to use in the traditional medical practices. However, its molecular mechanism on the tumor protection and therapy was not clearly elucidated. In this study, we investigated the possibility that extract of A. lavandulaefolia inhibits in vitro angiogenesis. Therefore, we examined the effect of extract of A. lavandulaefolia on the vascular network formation of human umbilical vein endothelial cells (HUVECs). We found that the treatment of A. lavandulaefolia extract suppressed the tube formation of HUVECs without any influence on the viability of HUVECs. In addition, extract of A. lavandulaefolia inhibited the migration and invasion of HUVECs. These results suggest that extract of A. lavandulaefolia could be act for an angiogenic inhibitor.
血管生成是肿瘤生长和转移的重要过程。抗血管生成靶向治疗最近已成为新的抗癌治疗策略。天然产物如传统药物是血管生成抑制剂的主要来源。已知薰衣草叶艾蒿可用于传统医学实践。然而，其对肿瘤保护和治疗的分子机制尚未明确阐明。在本研究中，我们研究了薰衣草叶艾蒿提取物抑制体外血管生成的可能性。因此，我们检测了薰衣草叶艾蒿提取物对人脐静脉内皮细胞（HUVECs）血管网络形成的影响。我们发现，薰衣草叶艾蒿提取物处理可抑制HUVECs的管腔形成，而对HUVECs的活力没有任何影响。此外，薰衣草叶艾蒿提取物抑制了HUVECs的迁移和侵袭。这些结果表明，薰衣草叶艾蒿提取物可能作为一种血管生成抑制剂发挥作用。
