Zhang Wenjie, Sun Beicheng
Liver Transplantation Center of the First Affiliated Hospital and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, P.R. China.
Oncotarget. 2015 Jan 20;6(2):633-41. doi: 10.18632/oncotarget.2719.
BACKGROUND & AIMS: The risk of liver cancer (LC) is regarded as age dependent. However, the influence of age on its prognosis is controversial. The aim of our study was to compare the long-term survival of younger versus older patients with LC.
In this retrospective study, we searched Surveillance, Epidemiology, and End-RESULTS (SEER) population-based data and identified 27,255 patients diagnosed with LC between 1988 and 2003. These patients were categorized into younger (45 years and under) and older age (over 45 years of age) groups. Five-year cancer specific survival data was obtained. Kaplan-Meier methods and multivariable Cox regression models were used to analyze long-term survival outcomes and risk factors.
There were significant differences between groups with regards to pathologic grading, histologic type, stage, and tumor size (p < 0.001). The 5-year liver cancer specific survival (LCSS) rates in the younger and older age groups were 14.5% and 8.4%, respectively (p < 0.001 by univariate and multivariate analysis). A stratified analysis of age on cancer survival showed only localized and regional stages to be validated as independent predictors, but not for advanced stages.
Compared to older patients, younger patients with LC have a higher LCSS after surgery, despite the poorer biological behavior of this carcinoma.
肝癌（LC）风险被认为与年龄相关。然而，年龄对其预后的影响存在争议。我们研究的目的是比较年轻与老年肝癌患者的长期生存率。
在这项回顾性研究中，我们检索了基于监测、流行病学和最终结果（SEER）的人群数据，确定了1988年至2003年间诊断为肝癌的27255例患者。这些患者被分为年轻组（45岁及以下）和老年组（45岁以上）。获得了5年癌症特异性生存数据。采用Kaplan-Meier方法和多变量Cox回归模型分析长期生存结果和危险因素。
两组在病理分级、组织学类型、分期和肿瘤大小方面存在显著差异（p<0.001）。年轻组和老年组的5年肝癌特异性生存率（LCSS）分别为14.5%和8.4%（单变量和多变量分析p<0.001）。对癌症生存的年龄分层分析显示，只有局部和区域分期被确认为独立预测因素，而晚期则不然。
与老年患者相比，年轻肝癌患者术后的LCSS更高，尽管该癌症的生物学行为较差。
