Liao Xiaoling, Lu Shaoying, Zhuo Yue, Winter Christina, Xu Wenfeng, Li Bo, Wang Yingxiao
Biomaterials and Live Cell Imaging Institute, School of Metallurgy and Materials Engineering, Chongqing University of Science and technology, Chongqing, 401331, P.R. China ; Department of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801.
Department of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801.
Cell Mol Bioeng. 2011 Dec;4(4):579-590. doi: 10.1007/s12195-011-0204-9.
Professor Shu Chien is a world-renowned leader and founder of Bioengineering. In particular, he has made seminal contributions to advancing our systematic and insightful understanding of how cells perceive their physical/mechanical environment and coordinate cellular functions. In this review, as part of a tribute to Prof. Shu Chien's scientific achievement, we summarize the research progress in understanding the physiology of bone cells interacting with different mechanical/physical environments during bone tissue regeneration/repair. We first introduce the cellular composition of the bone tissue and the mechanism of the physiological bone regeneration/repair process. We then describe the properties and development of biomaterials for bone tissue engineering, followed by the highlighting of research progresses on the cellular response to mechanical environmental cues. Finally, several latest advancements in bone tissue regeneration and remaining challenges in the field are discussed for future research directions.
舒钱教授是生物工程领域举世闻名的领导者和奠基人。特别是，他在推动我们系统且深入地理解细胞如何感知其物理/机械环境并协调细胞功能方面做出了开创性贡献。在这篇综述中，作为对舒钱教授科学成就的致敬，我们总结了在理解骨组织再生/修复过程中与不同机械/物理环境相互作用的骨细胞生理学方面的研究进展。我们首先介绍骨组织的细胞组成以及生理性骨再生/修复过程的机制。然后我们描述骨组织工程生物材料的特性和发展，接着重点介绍细胞对机械环境信号反应的研究进展。最后，讨论了骨组织再生的一些最新进展以及该领域尚存的挑战，以指明未来的研究方向。
