通往具有强效细胞毒性的阿斯马琳的亚硝基嘌呤。
Nitrosopurines en route to potently cytotoxic asmarines.
作者信息
Wan Kanny K, Iwasaki Kotaro, Umotoy Jeffrey C, Wolan Dennis W, Shenvi Ryan A
机构信息
Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037 (USA).
出版信息
Angew Chem Int Ed Engl. 2015 Feb 16;54(8):2410-5. doi: 10.1002/anie.201411493. Epub 2015 Jan 7.
Abstract
A nitrosopurine ene reaction easily assembles the asmarine pharmacophore and transmits remote stereochemistry to the diazepine-purine hetereocycle. This reaction generates potent cytotoxins which exceed the potency of asmarine A (1.2 μM IC50) and supersede the metabolites as useful leads for biological discovery.
摘要
亚硝基嘌呤烯反应能够轻松组装海葱胺药效基团，并将远程立体化学传递至二氮杂卓 - 嘌呤杂环。该反应生成了强效细胞毒素，其活性超过海葱胺A（IC50为1.2 μM），并且作为生物发现的有用先导物，其活性超过了代谢产物。
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