Lindgren Maija, Manninen Marko, Kalska Hely, Mustonen Ulla, Laajasalo Taina, Moilanen Kari, Huttunen Matti O, Cannon Tyrone D, Suvisaari Jaana, Therman Sebastian
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland.
Institute of Behavioural Sciences (Discipline of Psychology), University of Helsinki, Helsinki, Finland.
Early Interv Psychiatry. 2017 Apr;11(2):113-122. doi: 10.1111/eip.12218. Epub 2015 Jan 13.
We investigated the associations between clinical high-risk for psychosis (CHR), psychotic-like symptoms and suicidality among adolescent psychiatric patients.
The sample consisted of 54 CHR and 107 non-CHR psychiatric patients aged 15-18 in Helsinki, Finland, who were assessed at the beginning of their psychiatric treatment with the Structured Interview for Prodromal Syndromes (SIPS). Current suicidality was measured with the Beck Depression Inventory (item 9), while lifetime suicidality was evaluated from all available data, including patient files. The participants were followed for 2.8-8.9 years via the national hospital discharge register, with the follow-up outcome being intentional self-harm. Data on suicides were also gathered from the Causes of Death statistics.
Only 30.5% of the adolescents had no suicidal ideation at the beginning of their treatment. CHR risk state and SIPS-assessed delusions, suspiciousness, and hallucinations were associated with higher current suicidality. Of the 154 adolescents with register follow-up, there were five (3.2%) with intentional self-harm resulting in hospital treatment, all female. CHR status was not associated with self-harm. Current suicidality, familial risk of psychosis, and SIPS decreased expression of emotions were associated with self-harm during follow-up. In a Cox regression analysis model among girls, only decreased expression of emotions remained a significant predictor of intentional self-harm. Baseline suicidality measures were not associated with transitions to psychosis.
CHR status was associated with higher current suicidality but did not predict follow-up intentional self-harm in treatment-seeking adolescents. Decreased expression of emotions may indicate higher risk of intentional self-harm in adolescent treatment-seeking girls.
我们调查了青少年精神病患者中精神病临床高危(CHR)、类精神病症状与自杀倾向之间的关联。
样本包括芬兰赫尔辛基54名CHR和107名非CHR的15至18岁精神病患者,他们在精神病治疗开始时接受了前驱综合征结构化访谈(SIPS)评估。当前自杀倾向用贝克抑郁量表(第9项)测量,而终生自杀倾向则根据所有可用数据进行评估,包括患者档案。通过国家医院出院登记册对参与者进行了2.8至8.9年的随访,随访结果为故意自伤。自杀数据也从死亡原因统计中收集。
只有30.5%的青少年在治疗开始时没有自杀意念。CHR风险状态以及SIPS评估的妄想、猜疑和幻觉与当前较高的自杀倾向相关。在154名有登记随访的青少年中,有5名(3.2%)故意自伤并住院治疗,均为女性。CHR状态与自伤无关。当前自杀倾向、精神病家族风险以及SIPS中情感表达减少与随访期间的自伤相关。在女孩的Cox回归分析模型中,只有情感表达减少仍然是故意自伤的显著预测因素。基线自杀倾向测量与向精神病的转变无关。
CHR状态与当前较高的自杀倾向相关,但不能预测寻求治疗的青少年的随访期间故意自伤。情感表达减少可能表明寻求治疗的青春期女孩故意自伤的风险较高。