Servus Anda Polyclinic for Ophthalmology, Split, Croatia.
Department of Ophthalmology, Zagreb University Hospital Center, Zagreb, Croatia.
Acta Clin Croat. 2023 Aug;62(2):283-290. doi: 10.20471/acc.2023.62.02.05.
This study aimed to investigate the effect of palpebral fissure height in primary gaze position in healthy individuals on tear film stability. In this cross-sectional study, 120 subjects (60 male and female each) were enrolled and divided according to age into two groups, i.e., group 1 (aged 18-50 years) and group 2 (aged 51 and older). Palpebral fissure height on both eyes was measured in primary gaze position with a clear plastic ruler held in a central vertical position between the upper and lower lid margin, and the standard tear break-up time (TBUT) test was performed to evaluate tear film stability. Palpebral fissure height was significantly higher in younger than older subjects in all measurements on both eyes (p<0.001), and TBUT was shorter in older than in younger subjects. In all subjects included in the study, palpebral fissure height was not related to TBUT (p=0.589). However, analyzing the two age groups separately, a significant negative correlation was found between the palpebral fissure height and TBUT in both groups of younger (p<0.001) and older (p=0.009) subjects. In conclusion, an enlarged exposed ocular surface due to higher palpebral fissure height in healthy individual's primary gaze position negatively affects tear film stability expressed by TBUT.
本研究旨在探讨正常人第一眼位时睑裂高度对泪膜稳定性的影响。在这项横断面研究中,共纳入 120 名受试者(男女各 60 名),并根据年龄分为两组,即第 1 组(18-50 岁)和第 2 组(51 岁及以上)。在第一眼位,使用透明塑料直尺置于上、下睑缘中央垂直位置测量双眼睑裂高度,行标准泪膜破裂时间(TBUT)检查以评估泪膜稳定性。所有测量值中,年轻组的睑裂高度均明显高于老年组(p<0.001),且老年组的 TBUT 短于年轻组(p<0.001)。在所有纳入研究的受试者中,睑裂高度与 TBUT 无相关性(p=0.589)。然而,分别分析两个年龄组,发现年轻组(p<0.001)和老年组(p=0.009)的睑裂高度与 TBUT 呈显著负相关。总之,在健康个体第一眼位时,由于睑裂高度增加导致暴露的眼表增大,会对 TBUT 所表示的泪膜稳定性产生负面影响。