Sharma Kopal, Sharma Amit, Aseri Ml, Batta Angelika, Singh Vikas, Pilania Dinesh, Kumar Sharma Yogesh
Senior Demonstrator, Department of Pharmacology, Mahatma Gandhi Medical College & Hospital , Jaipur, India .
Reader, Department of Oral & Maxillofacial Surgery, Rajasthan Dental College , Jaipur, India .
J Clin Diagn Res. 2014 Nov;8(11):ZC01-4. doi: 10.7860/JCDR/2014/10378.5092. Epub 2014 Nov 20.
Pain control is one of the most important factors for successful treatment. Each new measure to control pain has been looked as miraculous act at the initial stages. The improvements in agents and techniques for local anaesthesia are probably the most important advances in dental science to have occurred in the past years.
To evaluate 4% articaine hydrochloride against 2% lignocaine hydrochloride anaesthesia in providing adequate palatal anaesthesia in maxillary posterior regions, without the need for a palatal block.
Healthy patients above 15 y of age and requiring bilateral extraction of their maxillary posterior teeth were included in this crossover study. The exclusion criteria included medical history of cardiovascular and kidney diseases, gastrointestinal bleeding or ulceration, allergic reactions to local anaesthetic, pregnancy or current lactation.
Eighty patients, requiring bilateral extraction of their teeth due to various reasons were enrolled for this study. Each patient received both lignocaine and articaine anaesthetic in equivalent dose at two different appointments. Maxillary infiltration technique was used for extraction of maxillary posterior teeth at both the appointments. A 170-mm Heft Parker visual analogue scale was used to assess the pain on the palatal mucosa after buccal infiltration of either anaesthetic agent. Blood pressure, Pulse rate and electrocardiographic monitoring were done during the procedure. Adverse effects during the study period were also monitored.
Data was analysed by Z-test and student's t-test.
Pain scores on probing palatal mucosa after buccal infiltration of the anaesthetic were more for lignocaine as compare to articaine and it was statistically significant (p <.001). However, for hemodynamic parameters and electrocardiographic monitoring, there was no statistically significant difference in blood pressure, pulse rate and electrocardiograph before and after the completion of extraction (p > 0.05).
Four percent articaine offers better clinical performance than 2% Lignocaine, particularly in terms of providing adequate palatal anaesthesia with only buccal infiltration.
疼痛控制是成功治疗的最重要因素之一。在最初阶段,每一种新的疼痛控制措施都被视为神奇之举。局部麻醉剂和技术的改进可能是过去几年牙科科学中最重要的进展。
评估4%盐酸阿替卡因与2%盐酸利多卡因麻醉在上颌后牙区提供足够的腭部麻醉而无需腭部阻滞的效果。
本交叉研究纳入了年龄在15岁以上、需要双侧拔除上颌后牙的健康患者。排除标准包括心血管和肾脏疾病病史、胃肠道出血或溃疡、对局部麻醉剂过敏、怀孕或当前哺乳期。
80名因各种原因需要双侧拔牙的患者参与了本研究。每位患者在两次不同的就诊时接受等量的利多卡因和阿替卡因麻醉。两次就诊时均采用上颌浸润技术拔除上颌后牙。使用170毫米的 Heft Parker视觉模拟量表评估在颊侧浸润任何一种麻醉剂后腭黏膜的疼痛程度。在手术过程中进行血压、脉搏率和心电图监测。还监测了研究期间的不良反应。
数据采用Z检验和学生t检验进行分析。
与阿替卡因相比,利多卡因颊侧浸润后探查腭黏膜时的疼痛评分更高,且具有统计学意义(p <.001)。然而,对于血流动力学参数和心电图监测,拔牙完成前后的血压、脉搏率和心电图无统计学显著差异(p > 0.05)。
4%阿替卡因比2%利多卡因具有更好的临床表现,特别是在仅通过颊侧浸润就能提供足够的腭部麻醉方面。