Hendricks Peter S, Thorne Christopher B, Clark C Brendan, Coombs David W, Johnson Matthew W
Department of Health Behavior, University of Alabama at Birmingham, Birmingham, AL, USA
Department of Health Behavior, University of Alabama at Birmingham, Birmingham, AL, USA.
J Psychopharmacol. 2015 Mar;29(3):280-8. doi: 10.1177/0269881114565653. Epub 2015 Jan 13.
Mental health problems are endemic across the globe, and suicide, a strong corollary of poor mental health, is a leading cause of death. Classic psychedelic use may occasion lasting improvements in mental health, but the effects of classic psychedelic use on suicidality are unknown. We evaluated the relationships of classic psychedelic use with psychological distress and suicidality among over 190,000 USA adult respondents pooled from the last five available years of the National Survey on Drug Use and Health (2008-2012) while controlling for a range of covariates. Lifetime classic psychedelic use was associated with a significantly reduced odds of past month psychological distress (weighted odds ratio (OR)=0.81 (0.72-0.91)), past year suicidal thinking (weighted OR=0.86 (0.78-0.94)), past year suicidal planning (weighted OR=0.71 (0.54-0.94)), and past year suicide attempt (weighted OR=0.64 (0.46-0.89)), whereas lifetime illicit use of other drugs was largely associated with an increased likelihood of these outcomes. These findings indicate that classic psychedelics may hold promise in the prevention of suicide, supporting the view that classic psychedelics' most highly restricted legal status should be reconsidered to facilitate scientific study, and suggesting that more extensive clinical research with classic psychedelics is warranted.
心理健康问题在全球范围内普遍存在，而自杀作为心理健康不佳的一个重要后果，是主要的死亡原因之一。使用经典迷幻剂可能会使心理健康状况得到持久改善，但经典迷幻剂的使用对自杀倾向的影响尚不清楚。我们在控制一系列协变量的同时，评估了在过去五年（2008 - 2012年）美国国家药物使用和健康调查中汇总的超过19万名成年受访者中，经典迷幻剂的使用与心理困扰和自杀倾向之间的关系。终生使用经典迷幻剂与过去一个月心理困扰的几率显著降低相关（加权优势比（OR）=0.81（0.72 - 0.91）），过去一年自杀念头（加权OR = 0.86（0.78 - 0.94）），过去一年自杀计划（加权OR = 0.71（0.54 - 0.94）），以及过去一年自杀未遂（加权OR = 0.64（0.46 - 0.89））相关，而终生非法使用其他药物在很大程度上与这些结果的可能性增加相关。这些发现表明，经典迷幻剂在预防自杀方面可能具有前景，支持应重新考虑经典迷幻剂最严格的法律地位以促进科学研究的观点，并表明有必要对经典迷幻剂进行更广泛的临床研究。
