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以不明原因不孕症为主要表现的乳糜泻:一例报告及文献综述

Unexplained infertility as primary presentation of celiac disease, a case report and literature review.

作者信息

Ghadir Mohammadreza, Iranikhah Abolfazl, Jandaghi Mahboubeh, Joukar Farahnaz, Sedigh-Rahimabadi Massih, Mansour-Ghanaei Fariborz

机构信息

Department of Gastroenterology, Qom University of Medical Sciences, Qom, Iran.

Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.

出版信息

Iran J Reprod Med. 2011 Spring;9(2):135-40.

PMID:25587261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4216449/
Abstract

BACKGROUND

Celiac sprue (gluten sensitive enteropathy) is an autoimmune disease which is hereditary and its pathology mainly bases on immunologic intolerance to gluten. It has a vast variety of signs and symptoms and its clinical features range from a silent disease to a typical gastrointestinal disorder. In this study we reviewed and summarized some other related issues about this disease and its relation with infertility.

CASE

The case is a 26 years old lady who had referred to a gynecologist because of infertility for 2 years and later it revealed that she has celiac sprue.

CONCLUSION

Screening for its silent or subtle types especially among suspicious cases such as unexplained infertility seems to be a cost effective action. Meanwhile, in time administration of a gluten-free diet can lead to an almost complete cure.

摘要

背景

乳糜泻(麸质敏感性肠病)是一种遗传性自身免疫性疾病,其病理主要基于对麸质的免疫不耐受。它有各种各样的体征和症状,临床特征从无症状疾病到典型的胃肠道疾病不等。在本研究中,我们回顾并总结了关于该疾病及其与不孕症关系的一些其他相关问题。

病例

该病例为一名26岁女性,因不孕2年转诊至妇科医生处,后来发现她患有乳糜泻。

结论

筛查其无症状或隐匿型,尤其是在不明原因不孕等可疑病例中,似乎是一项具有成本效益的措施。同时,及时给予无麸质饮食可导致几乎完全治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec5a/4216449/fdc73c2b87d1/ijrm-9-135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec5a/4216449/b9b0b859851d/ijrm-9-135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec5a/4216449/fdc73c2b87d1/ijrm-9-135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec5a/4216449/b9b0b859851d/ijrm-9-135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec5a/4216449/fdc73c2b87d1/ijrm-9-135-g002.jpg

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引用本文的文献

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Antibodies (Basel). 2023 Dec 6;12(4):79. doi: 10.3390/antib12040079.
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Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?乳糜泻的肠外表现:2022年我们应该了解什么?
J Clin Med. 2022 Jan 4;11(1):258. doi: 10.3390/jcm11010258.

本文引用的文献

1
Celiac disease.乳糜泻
Am Fam Physician. 2007 Dec 15;76(12):1795-802.
2
Celiac disease: variations of presentations in adults.乳糜泻:成人临床表现的多样性
Indian J Gastroenterol. 2007 Jul-Aug;26(4):162-6.
3
Complications of coeliac disease: are all patients at risk?乳糜泻的并发症:所有患者都有风险吗?
Postgrad Med J. 2006 Nov;82(973):705-12. doi: 10.1136/pgmj.2006.048876.
4
AGA Institute Medical Position Statement on the Diagnosis and Management of Celiac Disease.美国胃肠病学会关于乳糜泻诊断和管理的医学立场声明。
Gastroenterology. 2006 Dec;131(6):1977-80. doi: 10.1053/j.gastro.2006.10.003.
5
Prevalence of celiac disease in an urban area of Brazil with predominantly European ancestry.巴西一个以欧洲血统为主的城市地区乳糜泻的患病率。
World J Gastroenterol. 2006 Oct 28;12(40):6546-50. doi: 10.3748/wjg.v12.i40.6546.
6
Systematic review: the use of serology to exclude or diagnose coeliac disease (a comparison of the endomysial and tissue transglutaminase antibody tests).系统评价:血清学检测在排除或诊断乳糜泻中的应用(肌内膜抗体与组织转谷氨酰胺酶抗体检测的比较)
Aliment Pharmacol Ther. 2006 Jul 1;24(1):47-54. doi: 10.1111/j.1365-2036.2006.02967.x.
7
Celiac disease.乳糜泻
Orphanet J Rare Dis. 2006 Mar 1;1:3. doi: 10.1186/1750-1172-1-3.
8
New strategies for diagnosis and management of celiac disease.乳糜泻诊断与管理的新策略
J Am Osteopath Assoc. 2006 Mar;106(3):145-51.
9
The many faces of celiac disease: clinical presentation of celiac disease in the adult population.乳糜泻的多面性:成人乳糜泻的临床表现
Gastroenterology. 2005 Apr;128(4 Suppl 1):S74-8. doi: 10.1053/j.gastro.2005.02.016.
10
Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease?乳糜泻的流行病学:乳糜泻的患病率、发病率和病程进展情况如何?
Gastroenterology. 2005 Apr;128(4 Suppl 1):S47-51. doi: 10.1053/j.gastro.2005.02.030.