Mohammed Seif Eldin A, Kabashi Ahmed S, Koko Waleed S, Azim M Kamran
a Environment and Natural Resources Research Institute, National Centre for Research , P.O. Box 6096, Khartoum , Sudan.
b Medicinal and Aromatic Plants Research Institute, National Centre for Research , P.O. Box 2404, Khartoum , Sudan.
Nat Prod Res. 2015;29(22):2100-2. doi: 10.1080/14786419.2014.986659. Epub 2015 Jan 14.
Natural honey contains an array of glycoproteins, proteoglycans and glycopeptides. Size-exclusion chromatography fractionated Ziziphus honey proteins into five peaks with molecular masses in the range from 10 to >200 kDa. The fractionated proteins exhibited in vitro activities against Giardia lamblia with IC50 values ≤ 25 μg/mL. Results indicated that honey proteins were more active as antiprotozoal agents than metronidazole. This study indicated the potential of honey proteins and peptides as novel antigiardial agents.
天然蜂蜜含有一系列糖蛋白、蛋白聚糖和糖肽。尺寸排阻色谱法将枣属蜂蜜蛋白分离为五个峰，分子量范围为10至>200 kDa。分离出的蛋白在体外对蓝氏贾第鞭毛虫具有活性，IC50值≤25μg/mL。结果表明，蜂蜜蛋白作为抗原生动物剂比甲硝唑更具活性。本研究表明蜂蜜蛋白和肽作为新型抗贾第虫剂的潜力。
