François-Bellan A M, Segu L, Héry M
Laboratoire de Médecine Expérimentale, INSERM U297, Marseille, France.
Brain Res. 1989 Nov 27;503(1):144-7. doi: 10.1016/0006-8993(89)91715-0.
Using in vitro quantitative autoradiography we studied the in vivo effects of estradiol on GABAA and GABAB receptors in the rat brain. In all the areas studied (suprachiasmatic nucleus, medial preoptic area, striatum, frontal cortex), estradiol failed to significantly affect the GABAA receptor density. Chronic treatment with estradiol led however in the suprachiasmatic nucleus and the striatum to a decrease in the density of GABAB receptors. GABAB receptor regulation by estradiol was found to be area-specific within the hypothalamus since it was not observed in the medial preoptic area. The down regulation of GABAB receptors in the suprachiasmatic nucleus induced by estradiol treatment might thus explain the inhibitory effect of the steroid on the GABA control of serotonin metabolism we recently reported.
我们使用体外定量放射自显影技术研究了雌二醇对大鼠脑内GABAA和GABAB受体的体内作用。在所有研究区域（视交叉上核、内侧视前区、纹状体、额叶皮质），雌二醇未能显著影响GABAA受体密度。然而，雌二醇的慢性治疗导致视交叉上核和纹状体中GABAB受体密度降低。发现雌二醇对GABAB受体的调节在下丘脑内具有区域特异性，因为在内侧视前区未观察到这种调节。因此，雌二醇治疗诱导的视交叉上核中GABAB受体的下调可能解释了我们最近报道的该类固醇对血清素代谢的GABA控制的抑制作用。
