Ruberto Franco, Bergantino Bartolomeo, Testa Maria Cristina, D'Arena Carmen, Bernardinetti Mattia, Diso Daniele, De Giacomo Tiziano, Venuta Federico, Pugliese Francesco
1 Department of Anesthesiology and Intensive Care, "La Sapienza" University of Rome, Rome - Italy.
Int J Artif Organs. 2014 Dec;37(12):911-7. doi: 10.5301/ijao.5000375. Epub 2015 Jan 13.
Low-flow extracorporeal CO2 removal devices are easy to setup and manage and may provide valuable ventilation support.
We employed a new device (ProLUNG) recently introduced into the clinical arsenal that exploits a simple hemoperfusion technique sustained by blood flows lower than 500 ml/min to remove CO2 from the venous blood. It was used as an adjunctive support to mechanical ventilation during and after four lung transplantations in our center.
Two patients with cystic fibrosis, one with pulmonary fibrosis, and one with emphysema were included. They underwent lung transplantation and presented hypercapnia and respiratory acidosis before, during, or after the surgical procedure. After 1 h of treatment with the ProLUNG circuit, all patients showed reduced CO2 levels and increased pH; these variables remained stable until the end of treatment.
Our data suggest that this new device is effective in removing CO2 and stabilizing the pH.
低流量体外二氧化碳清除装置易于设置和管理，可能提供有价值的通气支持。
我们采用了一种最近引入临床的新装置（ProLUNG），该装置利用一种简单的血液灌流技术，由低于500毫升/分钟的血流维持，以从静脉血中清除二氧化碳。在我们中心的4例肺移植手术期间及术后，它被用作机械通气的辅助支持。
纳入了2例囊性纤维化患者、1例肺纤维化患者和1例肺气肿患者。他们接受了肺移植手术，在手术前、手术期间或手术后出现高碳酸血症和呼吸性酸中毒。使用ProLUNG回路治疗1小时后，所有患者的二氧化碳水平均降低，pH值升高；这些变量在治疗结束前一直保持稳定。
我们的数据表明，这种新装置在清除二氧化碳和稳定pH值方面是有效的。
