Rutter Jared, Hughes Adam L
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Trends Endocrinol Metab. 2015 Feb;26(2):59-68. doi: 10.1016/j.tem.2014.12.002. Epub 2015 Jan 12.
The budding yeast Saccharomyces cerevisiae has served as a remarkable model organism for numerous seminal discoveries in biology. This paradigm extends to the mitochondria, a central hub for cellular metabolism, where studies in yeast have helped to reinvigorate the field and launch an exciting new era in mitochondrial biology. Here we discuss a few recent examples in which yeast research has laid a foundation for our understanding of evolutionarily conserved mitochondrial processes and functions, from key factors and pathways involved in the assembly of oxidative phosphorylation (OXPHOS) complexes to metabolite transport, lipid metabolism, and interorganelle communication. We also highlight new areas of yeast mitochondrial biology that are likely to aid in our understanding of the mitochondrial etiology of disease in the future.
出芽酵母酿酒酵母已成为生物学中众多开创性发现的卓越模式生物。这一范例延伸到了线粒体，它是细胞代谢的核心枢纽，在酵母中的研究有助于重振该领域，并开启线粒体生物学令人兴奋的新时代。在此，我们讨论一些近期的例子，其中酵母研究为我们理解进化上保守的线粒体过程和功能奠定了基础，从参与氧化磷酸化（OXPHOS）复合物组装的关键因子和途径到代谢物转运、脂质代谢和细胞器间通讯。我们还强调了酵母线粒体生物学的新领域，这些领域未来可能有助于我们理解疾病的线粒体病因。
