Kim Kibeom, Park Myoung-Hwan
Convergence Research Center, Nanobiomaterials Institute, Sahmyook University, Seoul 01795, Republic of Korea.
Department of Chemistry and Life Science, Sahmyook University, Seoul 01795, Republic of Korea.
Biomedicines. 2024 Jan 16;12(1):202. doi: 10.3390/biomedicines12010202.
Peptide-functionalized nanomedicine, which addresses the challenges of specificity and efficacy in drug delivery, is emerging as a pivotal approach for cancer therapy. Globally, cancer remains a leading cause of mortality, and conventional treatments, such as chemotherapy, often lack precision and cause adverse effects. The integration of peptides into nanomedicine offers a promising solution for enhancing the targeting and delivery of therapeutic agents. This review focuses on the three primary applications of peptides: cancer cell-targeting ligands, building blocks for self-assembling nanostructures, and elements of stimuli-responsive systems. Nanoparticles modified with peptides improved targeting of cancer cells, minimized damage to healthy tissues, and optimized drug delivery. The versatility of self-assembled peptide structures makes them an innovative vehicle for drug delivery by leveraging their biocompatibility and diverse nanoarchitectures. In particular, the mechanism of cell death induced by self-assembled structures offers a novel approach to cancer therapy. In addition, peptides in stimuli-responsive systems enable precise drug release in response to specific conditions in the tumor microenvironment. The use of peptides in nanomedicine not only augments the efficacy and safety of cancer treatments but also suggests new research directions. In this review, we introduce systems and functionalization methods using peptides or peptide-modified nanoparticles to overcome challenges in the treatment of specific cancers, including breast cancer, lung cancer, colon cancer, prostate cancer, pancreatic cancer, liver cancer, skin cancer, glioma, osteosarcoma, and cervical cancer.
肽功能化纳米药物能够应对药物递送中的特异性和有效性挑战，正成为癌症治疗的关键方法。在全球范围内，癌症仍然是主要的死亡原因，而传统治疗方法，如化疗，往往缺乏精准性并会产生副作用。将肽整合到纳米药物中为增强治疗剂的靶向性和递送提供了一个有前景的解决方案。本综述聚焦于肽的三个主要应用：癌细胞靶向配体、自组装纳米结构的构建单元以及刺激响应系统的元件。用肽修饰的纳米颗粒改善了对癌细胞的靶向性，将对健康组织的损伤降至最低，并优化了药物递送。自组装肽结构的多功能性使其通过利用其生物相容性和多样的纳米结构成为药物递送的创新载体。特别是，自组装结构诱导的细胞死亡机制为癌症治疗提供了一种新方法。此外，刺激响应系统中的肽能够根据肿瘤微环境中的特定条件实现精确的药物释放。肽在纳米药物中的应用不仅提高了癌症治疗的疗效和安全性，还提出了新的研究方向。在本综述中，我们介绍了使用肽或肽修饰的纳米颗粒的系统和功能化方法，以克服在治疗包括乳腺癌、肺癌、结肠癌、前列腺癌、胰腺癌、肝癌、皮肤癌、神经胶质瘤、骨肉瘤和宫颈癌在内的特定癌症时所面临的挑战。
