• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从赤道到两极：有丝分裂和减数分裂中的染色体分离

From equator to pole: splitting chromosomes in mitosis and meiosis.

作者信息

Duro Eris, Marston Adèle L

机构信息

The Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom.

The Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom

出版信息

Genes Dev. 2015 Jan 15;29(2):109-22. doi: 10.1101/gad.255554.114.

DOI:10.1101/gad.255554.114
PMID:25593304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4298131/
Abstract

During eukaryotic cell division, chromosomes must be precisely partitioned to daughter cells. This relies on a mechanism to move chromosomes in defined directions within the parental cell. While sister chromatids are segregated from one another in mitosis and meiosis II, specific adaptations enable the segregation of homologous chromosomes during meiosis I to reduce ploidy for gamete production. Many of the factors that drive these directed chromosome movements are known, and their molecular mechanism has started to be uncovered. Here we review the mechanisms of eukaryotic chromosome segregation, with a particular emphasis on the modifications that ensure the segregation of homologous chromosomes during meiosis I.

摘要

在真核细胞分裂过程中，染色体必须精确地分配到子细胞中。这依赖于一种机制，使染色体在亲代细胞内沿特定方向移动。虽然姐妹染色单体在有丝分裂和减数分裂II中彼此分离，但特定的适应性变化使得同源染色体在减数分裂I期间能够分离，从而减少配子产生时的染色体倍性。许多驱动这些定向染色体移动的因素已为人所知，其分子机制也已开始被揭示。在这里，我们综述真核生物染色体分离的机制，特别强调确保同源染色体在减数分裂I期间分离的修饰。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/015b/4298131/dcf332d45e0b/109fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/015b/4298131/c53325bf9eb7/109fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/015b/4298131/207d0157a8da/109fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/015b/4298131/8f44806114ca/109fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/015b/4298131/dcf332d45e0b/109fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/015b/4298131/c53325bf9eb7/109fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/015b/4298131/207d0157a8da/109fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/015b/4298131/8f44806114ca/109fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/015b/4298131/dcf332d45e0b/109fig4.jpg

相似文献

1
From equator to pole: splitting chromosomes in mitosis and meiosis.从赤道到两极：有丝分裂和减数分裂中的染色体分离
Genes Dev. 2015 Jan 15;29(2):109-22. doi: 10.1101/gad.255554.114.
2
Spo13 maintains centromeric cohesion and kinetochore coorientation during meiosis I.Spo13在减数分裂I期间维持着丝粒凝聚力和动粒共定向。
Curr Biol. 2004 Dec 29;14(24):2168-82. doi: 10.1016/j.cub.2004.12.033.
3
Meiosis I chromosome segregation is established through regulation of microtubule-kinetochore interactions.减数分裂I染色体分离是通过对微管-动粒相互作用的调控来实现的。
Elife. 2012 Dec 18;1:e00117. doi: 10.7554/eLife.00117.
4
Sgo1 is required for co-segregation of sister chromatids during achiasmate meiosis I.Sgo1 对于非交换减数分裂 I 中姐妹染色单体的共分离是必需的。
Cell Cycle. 2011 Mar 15;10(6):951-5. doi: 10.4161/cc.10.6.15032.
5
The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis.极光B激酶AIR-2在有丝分裂期间调节动粒，在减数分裂期间同源染色体分离时是必需的。
Curr Biol. 2002 May 14;12(10):798-812. doi: 10.1016/s0960-9822(02)00820-5.
6
Kinetochore orientation during meiosis is controlled by Aurora B and the monopolin complex.减数分裂过程中动粒定向由极光激酶B和单极子复合体控制。
Cell. 2007 Feb 9;128(3):477-90. doi: 10.1016/j.cell.2006.12.040.
7
Meiosis I: when chromosomes undergo extreme makeover.减数分裂 I：染色体经历巨变。
Curr Opin Cell Biol. 2013 Dec;25(6):687-96. doi: 10.1016/j.ceb.2013.07.009. Epub 2013 Aug 2.
8
Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms.芽殖酵母中的染色体分离：姐妹染色单体黏连及相关机制。
Genetics. 2014 Jan;196(1):31-63. doi: 10.1534/genetics.112.145144.
9
Regulation of kinetochore configuration during mitosis.有丝分裂期间动粒构型的调控。
Curr Genet. 2018 Dec;64(6):1197-1203. doi: 10.1007/s00294-018-0841-9. Epub 2018 Apr 27.
10
Meiosis-specific distal cohesion site decoupled from the kinetochore.减数分裂特异性远端黏连位点与动粒解偶联。
Nat Commun. 2025 Mar 3;16(1):2116. doi: 10.1038/s41467-025-57438-w.

引用本文的文献

1
Oocyte development: it's all about quality.卵母细胞发育：关键在于质量。
Reprod Biomed Online. 2025 Apr;50(4):104804. doi: 10.1016/j.rbmo.2025.104804.
2
SGO2 does not play an essential role in separase inhibition during meiosis I in mouse oocytes.SGO2在小鼠卵母细胞减数分裂I期间的分离酶抑制中不发挥关键作用。
PLoS Biol. 2025 Apr 23;23(4):e3003131. doi: 10.1371/journal.pbio.3003131. eCollection 2025 Apr.
3
Cell cycle and age-related modulations of mouse chromosome stiffness.小鼠染色体硬度的细胞周期和年龄相关调节

本文引用的文献

1
Sister kinetochores are mechanically fused during meiosis I in yeast.姐妹着丝粒在酵母减数分裂 I 中发生机械融合。
Science. 2014 Oct 10;346(6206):248-51. doi: 10.1126/science.1256729. Epub 2014 Sep 11.
2
The kinetochore.动粒
Cold Spring Harb Perspect Biol. 2014 Jul 1;6(7):a015826. doi: 10.1101/cshperspect.a015826.
3
Sgo1 regulates both condensin and Ipl1/Aurora B to promote chromosome biorientation.Sgo1通过调控凝聚素和Ipl1/极光激酶B来促进染色体双定向。
Elife. 2025 Apr 14;13:RP97403. doi: 10.7554/eLife.97403.
4
Distinct chromatin regulators downmodulate meiotic axis formation and DNA break induction at chromosome ends.不同的染色质调节因子下调减数分裂轴的形成以及染色体末端的DNA断裂诱导。
bioRxiv. 2025 Mar 3:2025.02.27.640173. doi: 10.1101/2025.02.27.640173.
5
The functional organisation of the centromere and kinetochore during meiosis.减数分裂过程中着丝粒和动粒的功能组织
Curr Opin Cell Biol. 2025 Feb 26;94:102486. doi: 10.1016/j.ceb.2025.102486.
6
Distinct roles of spindle checkpoint proteins in meiosis.纺锤体检验点蛋白在减数分裂中的不同作用。
Curr Biol. 2024 Aug 19;34(16):3820-3829.e5. doi: 10.1016/j.cub.2024.07.025. Epub 2024 Jul 29.
7
Investigation of artificial cells containing the Par system for bacterial plasmid segregation and inheritance mimicry.研究含有 Par 系统的人工细胞，以模拟细菌质粒的分离和遗传。
Nat Commun. 2024 Jun 10;15(1):4956. doi: 10.1038/s41467-024-49412-9.
8
Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytes.生殖衰老：代谢对哺乳动物卵母细胞中与年龄相关的染色体错误分离的贡献。
Reproduction. 2024 Jun 28;168(2). doi: 10.1530/REP-23-0510. Print 2024 Aug 1.
9
Cell cycle and Age-Related Modulations of Mouse Chromosome Stiffness.小鼠染色体刚度的细胞周期及与年龄相关的调节
bioRxiv. 2025 Mar 10:2024.03.06.583771. doi: 10.1101/2024.03.06.583771.
10
Age-dependent loss of cohesion protection in human oocytes.人类卵母细胞中依赖年龄的黏连保护丧失。
Curr Biol. 2024 Jan 8;34(1):117-131.e5. doi: 10.1016/j.cub.2023.11.061. Epub 2023 Dec 21.
PLoS Genet. 2014 Jun 19;10(6):e1004411. doi: 10.1371/journal.pgen.1004411. eCollection 2014 Jun.
4
Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere.守护蛋白通过将凝聚素募集到着丝粒周围，使染色体偏向双定向排列。
Elife. 2014;3:e01374. doi: 10.7554/eLife.01374. Epub 2014 Feb 4.
5
Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms.芽殖酵母中的染色体分离：姐妹染色单体黏连及相关机制。
Genetics. 2014 Jan;196(1):31-63. doi: 10.1534/genetics.112.145144.
6
Meiotic recombination in mammals: localization and regulation.哺乳动物减数分裂重组：定位与调控。
Nat Rev Genet. 2013 Nov;14(11):794-806. doi: 10.1038/nrg3573.
7
Dual mechanisms prevent premature chromosome segregation during meiosis.双机制防止减数分裂过程中染色体过早分离。
Genes Dev. 2013 Oct 1;27(19):2139-46. doi: 10.1101/gad.227454.113.
8
Symmetry breaking and polarity establishment during mouse oocyte maturation.小鼠卵母细胞成熟过程中的对称性破缺和极性建立。
Philos Trans R Soc Lond B Biol Sci. 2013 Sep 23;368(1629):20130002. doi: 10.1098/rstb.2013.0002. Print 2013.
9
Initiation of meiotic recombination: how and where? Conservation and specificities among eukaryotes.减数分裂重组的起始：如何以及在哪里？真核生物的保守性和特异性。
Annu Rev Genet. 2013;47:563-99. doi: 10.1146/annurev-genet-110711-155423.
10
Polo kinase Cdc5 is a central regulator of meiosis I.Polo 激酶 Cdc5 是有丝分裂 I 的核心调节因子。
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14278-83. doi: 10.1073/pnas.1311845110. Epub 2013 Aug 5.