Oliviero A, Carrasco-López M C, Campolo M, Perez-Borrego Y A, Soto-León V, Gonzalez-Rosa J J, Higuero A M, Strange B A, Abad-Rodriguez J, Foffani G
FENNSI Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain.
FENNSI Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain.
Brain Stimul. 2015 May-Jun;8(3):481-5. doi: 10.1016/j.brs.2014.12.002. Epub 2014 Dec 11.
Transcranial static magnetic field stimulation (tSMS) in humans reduces cortical excitability.
The objective of this study was to determine if prolonged tSMS (2 h) could be delivered safely in humans. Safety limits for this technique have not been described.
tSMS was applied for 2 h with a cylindric magnet on the occiput of 17 healthy subjects. We assessed tSMS-related safety aspects at tissue level by measuring levels of neuron-specific enolase (NSE, a marker of neuronal damage) and S100 (a marker of glial reactivity and damage). We also included an evaluation of cognitive side effects by using a battery of visuomotor and cognitive tests.
tSMS did not induce any significant increase in NSE or S100. No cognitive alteration was detected.
Our data indicate that the application of tSMS is safe in healthy human subjects, at least within these parameters.
经颅静磁场刺激（tSMS）可降低人体皮质兴奋性。
本研究旨在确定长时间（2小时）经颅静磁场刺激是否能在人体安全进行。该技术的安全限度尚未有描述。
对17名健康受试者的枕部使用圆柱形磁体进行2小时经颅静磁场刺激。我们通过测量神经元特异性烯醇化酶（NSE，神经元损伤标志物）和S100（神经胶质反应性和损伤标志物）水平，在组织水平评估经颅静磁场刺激相关的安全性。我们还通过一系列视觉运动和认知测试对认知副作用进行了评估。
经颅静磁场刺激未引起NSE或S100的任何显著升高。未检测到认知改变。
我们的数据表明，经颅静磁场刺激在健康人体受试者中应用是安全的，至少在这些参数范围内是安全的。
