Godfrey Mark S, Finn Arkadiy, Zainah Hadeel, Dapaah-Afriyie Kwame
Department of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA.
Department of Medicine, Warren Alpert School of Medicine, Brown University, The Miriam Hospital, Providence, Rhode Island, USA.
BMJ Case Rep. 2015 Jan 16;2015:bcr2014206162. doi: 10.1136/bcr-2014-206162.
A 65-year-old woman with a diagnosis of Clostridium difficile colitis undergoing prolonged treatment with metronidazole was admitted to hospital for altered mentation, slurred speech and weakness. She was diagnosed with metronidazole-induced encephalopathy, confirmed with brain MRI and improved when the offending agent was removed. This case report highlights encephalopathy as a complication of prolonged metronidazole treatment, which has become more common in clinical practice for the treatment of C. difficile infection.
一名65岁诊断为艰难梭菌结肠炎且正在接受甲硝唑长期治疗的女性因精神状态改变、言语不清和虚弱入院。她被诊断为甲硝唑诱发的脑病，经脑部磁共振成像（MRI）确诊，停用致病药物后病情好转。本病例报告强调了脑病是甲硝唑长期治疗的一种并发症，在艰难梭菌感染的临床治疗中这种情况已变得更为常见。
