Gilbert Brian Wesley, Gabriel Ali, Velazquez Laura
Wesley Medical Center, Wichita, KS, USA.
Hosp Pharm. 2020 Oct;55(5):338-341. doi: 10.1177/0018578719844706. Epub 2019 May 9.
To report a case of posterior reversible encephalopathy syndrome (PRES) in a 75 year-old patient who was taking concomitant ciprofloxacin and metronidazole. Case report A patient had been prescribed ciprofloxacin and metronidazole during a recent hospitalization and continued this regimen outpatient. Two weeks after discharge and 3 weeks after initiation of her regimen, she was brought to the emergency department after developing acute weakness and lightheadedness. After admission, the patient declined more rapidly and began seizing with subsequent intubation. Initial computed tomographic (CT) imaging showed no acute neurological abnormalities, and a sepsis workup was initiated. After negative CT, a magnetic resonance imaging scan was performed that showed a T2 flair and hyperdensity consistent with PRES. The final diagnosis was considered to be PRES secondary to ciprofloxacin/metronidazole utilization. Antibiotic induced PRES is a condition that needs to be explored more thoroughly.
报告一例75岁患者发生的后部可逆性脑病综合征（PRES），该患者正在同时服用环丙沙星和甲硝唑。病例报告 一名患者近期住院期间被开具了环丙沙星和甲硝唑，并在门诊继续使用该治疗方案。出院两周后且开始用药三周后，她因出现急性虚弱和头晕被送往急诊科。入院后，患者病情迅速恶化并开始抽搐，随后进行了插管。最初的计算机断层扫描（CT）成像未显示急性神经异常，于是启动了脓毒症检查。CT检查结果为阴性后，进行了磁共振成像扫描，结果显示与PRES一致的T2加权像和高密度影。最终诊断为环丙沙星/甲硝唑使用继发的PRES。抗生素诱发的PRES是一种需要更深入研究的病症。
