Sugiyama H, Ito I, Watanabe M
Department of Cellular Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
Neuron. 1989 Jul;3(1):129-32. doi: 10.1016/0896-6273(89)90121-9.
Three major subtypes of glutamate receptors that are coupled to cation channels are known. Recently an additional subtype that is coupled to G proteins and stimulates inositol phospholipid metabolism (the metabotropic glutamate receptor) has been proposed. The pharmacological characteristics of this receptor have now been examined. Although it shares some agonists with N-methyl-D-aspartate- and quisqualate-subtype receptors, it shares virtually no antagonists with any of the three cation channel-coupled receptor subtypes. Thus the metabotropic glutamate receptor belongs to a receptor category that is completely different from that of the other three receptor subtypes, not only functionally, but also pharmacologically.
已知有三种与阳离子通道偶联的谷氨酸受体主要亚型。最近有人提出了另一种与G蛋白偶联并刺激肌醇磷脂代谢的亚型（代谢型谷氨酸受体）。现已对该受体的药理学特性进行了研究。尽管它与N-甲基-D-天冬氨酸和quisqualate亚型受体有一些共同的激动剂，但它与三种阳离子通道偶联受体亚型中的任何一种几乎都没有共同的拮抗剂。因此，代谢型谷氨酸受体不仅在功能上，而且在药理学上都属于与其他三种受体亚型完全不同的受体类别。
