Najafi M, Fardid R, Hadadi Gh, Fardid M
Department of Radiology, School of paramedical sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Health Management and Economics Research Center, Iran University of Medical Science, Tehran, Iran.
J Biomed Phys Eng. 2014 Dec 15;4(4):163-72. eCollection 2014 Dec.
The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. Responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. These changes are confirmed by results of some In-Vivo studies. Most well-known important factors affecting radiation-induced bystander effect include free radicals, immune system factors, expression changes of some genes involved in inflammation pathway and epigenetic factors.
辐射旁效应是指未受照射的细胞由于从附近受照射细胞接收到信号而表现出不同程度效应的现象。未受照射细胞的反应可能包括翻译过程、基因表达、细胞增殖、凋亡和细胞死亡的变化。一些体内研究结果证实了这些变化。影响辐射旁效应的最著名的重要因素包括自由基、免疫系统因素、参与炎症途径的一些基因的表达变化以及表观遗传因素。
