维生素D补充剂对非裔美国人肥胖的影响。
Impact of vitamin D supplementation on adiposity in African-Americans.
作者信息
Chandler P D, Scott J B, Drake B F, Ng K, Chan A T, Hollis B W, Emmons K M, Giovannucci E L, Fuchs C S, Bennett G G
机构信息
1] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA [2] Harvard Medical School, Boston, MA, USA.
Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
出版信息
Nutr Diabetes. 2015 Jan 19;5(1):e147. doi: 10.1038/nutd.2014.44.
BACKGROUND
African-Americans have higher rates of obesity-associated chronic diseases. Serum 25-hydroxyvitamin D (25(OH)D) shows an inverse association with obesity status. We investigated whether vitamin D supplementation changes body mass index (BMI).
SUBJECTS
In total, 328 overweight African-Americans were enrolled over three consecutive winter periods (2007-2010) into a randomized, double-blind, placebo-controlled trial to receive cholecalciferol supplementation (0, 1000 international units (IU), 2000 IU or 4000 IU per day) for 3 months. Plasma concentrations of 25(OH)D and anthropometric measurements were done at baseline, 3 and 6 months.
RESULTS
At 3 months, vitamin D supplementation in three dose groups (1000 IU, 2000 IU or 4000 IU per day) did not cause any significant changes in BMI as compared with placebo group 3-month change in BMI per 1000 IU per day estimate (SE): 0.01 (0.039); P=0.78.
CONCLUSIONS
In overweight African-Americans, short-term high-dose vitamin D supplementation did not alter BMI.
背景
非裔美国人患肥胖相关慢性病的比例较高。血清25-羟基维生素D（25(OH)D）与肥胖状况呈负相关。我们研究了补充维生素D是否会改变体重指数（BMI）。
研究对象
在连续三个冬季（2007 - 2010年），共招募了328名超重的非裔美国人，参与一项随机、双盲、安慰剂对照试验，接受为期3个月的胆钙化醇补充剂（每天0、1000国际单位（IU）、2000 IU或4000 IU）。在基线、3个月和6个月时测定血浆25(OH)D浓度和人体测量数据。
结果
在3个月时，与安慰剂组相比，三个剂量组（每天1000 IU、2000 IU或4000 IU）补充维生素D并未导致BMI有任何显著变化。每天每1000 IU估计的BMI 3个月变化（标准误）：0.01（0.039）；P = 0.78。
结论
在超重的非裔美国人中，短期高剂量补充维生素D并未改变BMI。
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