Impact of vitamin D supplementation on adiposity in African-Americans.
作者信息
Chandler P D, Scott J B, Drake B F, Ng K, Chan A T, Hollis B W, Emmons K M, Giovannucci E L, Fuchs C S, Bennett G G
机构信息
1] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA [2] Harvard Medical School, Boston, MA, USA.
Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
出版信息
Nutr Diabetes. 2015 Jan 19;5(1):e147. doi: 10.1038/nutd.2014.44.
BACKGROUND
African-Americans have higher rates of obesity-associated chronic diseases. Serum 25-hydroxyvitamin D (25(OH)D) shows an inverse association with obesity status. We investigated whether vitamin D supplementation changes body mass index (BMI).
SUBJECTS
In total, 328 overweight African-Americans were enrolled over three consecutive winter periods (2007-2010) into a randomized, double-blind, placebo-controlled trial to receive cholecalciferol supplementation (0, 1000 international units (IU), 2000 IU or 4000 IU per day) for 3 months. Plasma concentrations of 25(OH)D and anthropometric measurements were done at baseline, 3 and 6 months.
RESULTS
At 3 months, vitamin D supplementation in three dose groups (1000 IU, 2000 IU or 4000 IU per day) did not cause any significant changes in BMI as compared with placebo group 3-month change in BMI per 1000 IU per day estimate (SE): 0.01 (0.039); P=0.78.
CONCLUSIONS
In overweight African-Americans, short-term high-dose vitamin D supplementation did not alter BMI.
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