非裔美国人和尼日利亚女性的 25-羟维生素 D 水平。
25-hydroxyvitamin D levels in African American and Nigerian women.
机构信息
Department of Public Health Sciences, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA.
出版信息
Am J Hum Biol. 2013 Jul-Aug;25(4):560-2. doi: 10.1002/ajhb.22395. Epub 2013 Apr 4.
OBJECTIVES
African Americans (AA) have substantially lower levels of circulating 25-hydroxyvitamin D (25(OH)D) than whites. We compared population-based samples of 25(OH)D in women of African descent from Nigeria and metropolitan Chicago.
METHODS
One hundred women of Yoruba ethnicity from southwest Nigeria and 94 African American women from metropolitan Chicago were recruited and compared using a standardized survey protocol and the same laboratory assay for 25(OH)D.
RESULTS
Mean 25(OH)D levels were 64 nmol/l among the Nigerians and 29 nmol/l among the AA. Only 10% of the values were shared in common between the groups, and 76% of the Nigerians were above the currently defined threshold for adequate circulating 25(OH)D compared to 5% of the AA. Modest associations were seen between 25(OH)D and measures of obesity, although adjustment for these traits did not materially affect the group differences.
CONCLUSION
These data support the presumption that skin color is an adaptive trait which has evolved in part to regulate 25(OH)D. It remains undetermined, however, whether lower values observed in AA have negative health consequences.
目的
非裔美国人（AA）的循环 25-羟维生素 D（25（OH）D）水平明显低于白种人。我们比较了来自尼日利亚西南部和芝加哥都会区的非裔美国女性的基于人群的 25（OH）D 样本。
方法
从尼日利亚西南部的约鲁巴族裔中招募了 100 名女性，从芝加哥都会区招募了 94 名非裔美国女性，并使用标准化调查方案和相同的实验室检测 25（OH）D 对她们进行了比较。
结果
尼日利亚人的平均 25（OH）D 水平为 64nmol/L，非裔美国人的平均 25（OH）D 水平为 29nmol/L。两组之间只有 10%的数值是共同的，与 5%的非裔美国人相比，76%的尼日利亚人目前被定义为循环 25（OH）D 充足的阈值。尽管对这些特征进行调整，但 25（OH）D 与肥胖测量值之间存在适度关联，但并未对群体差异产生实质性影响。
结论
这些数据支持皮肤颜色是一种适应性特征的假设，它在一定程度上是为了调节 25（OH）D 而进化的。然而，目前尚不清楚非裔美国人中观察到的较低值是否会对健康产生负面影响。
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