Zang Yanqing, Zhang Liping, Igarashi Kiharu, Yu Changqing
College of Food Science, Heilongjiang Bayi Agricultural University, China.
Food Funct. 2015 Mar;6(3):834-41. doi: 10.1039/c4fo00844h.
The present study investigated the anti-obesity and anti-diabetic effects of kaempferol glycoside (KG) fractions which were composed of four kaempferol glycosides and purified from unripe Jindai-soybean (Edamame) leaves in C57BL/6J mice. High fat-fed mice treated with 0.15% dietary KG for 92 days had reduced body weight, adipose tissue and TG levels compared to the high fat-fed control group. KG-treatment also decreased fasting blood glucose, serum HbA1c (hemoglobin A(1c)) levels and improved insulin resistance. Gene expression analysis of the liver showed that KG decreased peroxisome proliferator-activated receptor (PPAR-γ) and sterol regulatory element-binding protein (SREBP-1c) expression. These results suggest that KG reduced the accumulation of adipose tissue, improving hyperlipidemia as well as diabetes in obese mice by increasing lipid metabolism through the downregulation of PPAR-γ and SREBP-1c. Thus, KG may have an anti-obesity and anti-diabetic potential.
本研究调查了山奈酚糖苷（KG）组分对C57BL/6J小鼠的抗肥胖和抗糖尿病作用。该组分由四种山奈酚糖苷组成，从嫩毛豆叶中纯化得到。与高脂喂养的对照组相比，用0.15%膳食KG处理92天的高脂喂养小鼠体重、脂肪组织和甘油三酯水平降低。KG处理还降低了空腹血糖、血清糖化血红蛋白（HbA1c）水平，并改善了胰岛素抵抗。肝脏的基因表达分析表明，KG降低了过氧化物酶体增殖物激活受体（PPAR-γ）和固醇调节元件结合蛋白（SREBP-1c）的表达。这些结果表明，KG通过下调PPAR-γ和SREBP-1c增加脂质代谢，减少脂肪组织积累，改善肥胖小鼠的高脂血症和糖尿病。因此，KG可能具有抗肥胖和抗糖尿病潜力。
