Trauma and Acute Critical Care Center, Tokyo Medical and Dental University Hospital of Medicine, 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan.
Department of Acute Critical Care and Disaster Medicine, Graduate School of Tokyo Medical and Dental University, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan.
Sci Rep. 2021 Aug 9;11(1):16147. doi: 10.1038/s41598-021-95443-3.
Few studies have investigated the relationship between blood type and trauma outcomes according to the type of injury. We conducted a retrospective multicenter observational study in twelve emergency hospitals in Japan. Patients with isolated severe abdominal injury (abbreviated injury scale for the abdomen ≥ 3 and that for other organs < 3) that occurred between 2008 and 2018 were divided into four groups according to blood type. The association between blood type and mortality, ventilator-free days (VFD), and total transfusion volume were evaluated using univariate and multivariate regression models. A total of 920 patients were included, and were divided based on their blood type: O, 288 (31%); A, 345 (38%); B, 186 (20%); and AB, 101 (11%). Patients with type O had a higher in-hospital mortality rate than those of other blood types (22% vs. 13%, p < 0.001). This association was observed in multivariate analysis (adjusted odds ratio [95% confidence interval] = 1.48 [1.25-2.26], p = 0.012). Furthermore, type O was associated with significantly higher cause-specific mortalities, fewer VFD, and larger transfusion volumes. Blood type O was associated with significantly higher mortality and larger transfusion volumes in patients with isolated severe abdominal trauma.
鲜有研究根据损伤类型调查过血型与创伤结局之间的关系。我们在日本 12 家急救医院开展了一项回顾性多中心观察性研究。将 2008 年至 2018 年间发生的单纯严重腹部损伤患者（腹部损伤严重程度评分≥3 分，其他器官损伤严重程度评分<3 分）分为四组，根据血型分组。采用单变量和多变量回归模型评估血型与死亡率、无呼吸机天数（VFD）和总输血量之间的关系。共纳入 920 例患者，根据血型分组：O 型，288 例（31%）；A型，345 例（38%）；B 型，186 例（20%）；AB 型，101 例（11%）。O 型患者院内死亡率高于其他血型（22%比 13%，p<0.001）。多变量分析显示，这种关联仍然存在（调整比值比[95%置信区间]：1.48[1.25-2.26]，p=0.012）。此外，O 型与较高的特定病因死亡率、较少的 VFD 和更大的输血量相关。在单纯严重腹部创伤患者中，O 型与更高的死亡率和更大的输血量显著相关。
