Fagherazzi Guy, Gusto Gaëlle, Clavel-Chapelon Françoise, Balkau Beverley, Bonnet Fabrice
Team 9, Nutrition, Hormones and Women's Health, Inserm U1018, Centre for Research in Epidemiology and Population Health, Gustave Roussy Institute, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France,
Diabetologia. 2015 Mar;58(3):519-22. doi: 10.1007/s00125-014-3472-9. Epub 2014 Dec 23.
AIMS/HYPOTHESIS: The objective of this study was to evaluate the relationship of ABO blood type (A, B, AB and O), Rhesus factor (positive or negative) and a combination of the two (ABO × Rhesus) with type 2 diabetes mellitus risk.
In total, 82,104 women from the large prospective E3N cohort were followed between 1990 and 2008. Multivariate Cox regression models were used to estimate HRs and 95% CIs.
Those with either the A (HR 1.10 [95% CI 1.02, 1.18]) or B (HR 1.21 [95% CI 1.07, 1.36]) group were at increased risk of type 2 diabetes mellitus compared with those with the O group. The association with the AB group did not reach statistical significance (HR 1.17 [95% CI 0.99, 1.39]). There was no difference in type 2 diabetes mellitus risk between Rhesus positive and negative groups (HR 0.96 [95% CI 0.88, 1.05]). When the universal donors (O(-)) were taken as the reference category, we observed an increased risk for both A(+) (HR 1.17 [95% CI 1.02, 1.35]) and A(-) (HR 1.22 [95% CI 1.03, 1.45]) individuals. The greatest increase in risk was seen for those with the B(+) blood group (HR 1.35 [95% CI 1.13, 1.60]). We also observed a greater type 2 diabetes mellitus risk for those with the AB(+) group (HR 1.26 [95% CI 1.02, 1.57]). Adjustment for fasting plasma glucose and lipid concentrations in a case-control subsample did not alter the associations.
CONCLUSIONS/INTERPRETATION: This study suggests that people with the O blood type have a lower risk of developing type 2 diabetes mellitus. Therefore, blood group should be investigated in future clinical and epidemiological studies on diabetes, and further pathophysiological research is needed to determine why individuals with blood type O have a lower risk of type 2 diabetes mellitus.
目的/假设：本研究的目的是评估ABO血型（A、B、AB和O）、恒河猴因子（阳性或阴性）以及两者的组合（ABO×恒河猴因子）与2型糖尿病风险之间的关系。
1990年至2008年期间，对大型前瞻性E3N队列中的82104名女性进行了随访。使用多变量Cox回归模型来估计风险比（HR）和95%置信区间（CI）。
与O型血的人相比，A型血（HR 1.10 [95% CI 1.02, 1.18]）或B型血（HR 1.21 [95% CI 1.07, 1.36]）的人患2型糖尿病的风险增加。与AB型血的关联未达到统计学显著性（HR 1.17 [95% CI 0.99, 1.39]）。恒河猴因子阳性和阴性组之间患2型糖尿病的风险没有差异（HR 0.96 [95% CI 0.88, 1.05]）。当将万能供血者（O(-)）作为参照类别时，我们观察到A(+)（HR 1.17 [95% CI 1.02, 1.35]）和A(-)（HR 1.22 [95% CI 1.03, 1.45]）个体的风险增加。风险增加最大的是B(+)血型的人（HR 1.35 [95% CI 1.13, 1.60]）。我们还观察到AB(+)组的人患2型糖尿病的风险更高（HR 1.26 [95% CI 1.02, 1.57]）。在病例对照子样本中对空腹血糖和血脂浓度进行调整后，这些关联没有改变。
结论/解读：本研究表明，O型血的人患2型糖尿病的风险较低。因此，在未来关于糖尿病的临床和流行病学研究中应调查血型，并且需要进一步的病理生理学研究来确定为什么O型血的个体患2型糖尿病的风险较低。
