Montreal Neurological Institute, McGill University, 3801 University Ave, #896, Montreal, QC H2V2A1, Canada.
Montreal Neurological Institute, McGill University, 3801 University Ave, #896, Montreal, QC H2V2A1, Canada; Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Neuron. 2015 Feb 4;85(3):615-27. doi: 10.1016/j.neuron.2014.12.043. Epub 2015 Jan 15.
Traveling waves of neural activity are frequently observed to occur in concert with the presentation of a sensory stimulus or the execution of a movement. Although such waves have been studied for decades, little is known about their function. Here we show that traveling waves in the primate extrastriate visual cortex provide a means of integrating sensory and motor signals. Specifically, we describe a traveling wave of local field potential (LFP) activity in cortical area V4 of macaque monkeys that is triggered by the execution of saccadic eye movements. These waves sweep across the V4 retinotopic map, following a consistent path from the foveal to the peripheral representations of space; their amplitudes correlate with the direction and size of each saccade. Moreover, these waves are associated with a reorganization of the postsaccadic neuronal firing patterns, which follow a similar retinotopic progression, potentially prioritizing the processing of behaviorally relevant stimuli.
神经活动的传播波经常与感觉刺激的呈现或运动的执行同时发生。尽管这种波已经被研究了几十年，但它们的功能却知之甚少。在这里，我们表明灵长类动物外纹状视觉皮层中的传播波为整合感觉和运动信号提供了一种手段。具体来说，我们描述了在猕猴的 V4 皮层区域中，由扫视眼动引发的局部场电位 (LFP) 活动的传播波。这些波在 V4 视网膜映射上扫过，沿着从中央凹到空间外周代表的一致路径进行；它们的幅度与每个扫视的方向和大小相关。此外，这些波与扫视后神经元放电模式的重新组织有关，这些模式遵循类似的视网膜映射进展，可能优先处理与行为相关的刺激。
