四氧嘧啶的微粒体还原产生四氧嘧啶阴离子自由基。 - Suppr

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超能文献

Microsomal reduction of alloxan produces alloxan anion radicals.

作者信息

Nukatsuka M, Sakurai H, Kawada J

机构信息

Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.

出版信息

Naturwissenschaften. 1989 Dec;76(12):574-5. doi: 10.1007/BF00462867.

DOI:10.1007/BF00462867

PMID:2560144

Abstract

摘要

相似文献

Microsomal reduction of alloxan produces alloxan anion radicals.四氧嘧啶的微粒体还原产生四氧嘧啶阴离子自由基。

Naturwissenschaften. 1989 Dec;76(12):574-5. doi: 10.1007/BF00462867.

Generation of alloxan free radicals in chemical and biological systems: implication in the diabetogenic action of alloxan.化学和生物系统中四氧嘧啶自由基的产生：对四氧嘧啶致糖尿病作用的影响。

Biochem Biophys Res Commun. 1989 Nov 30;165(1):278-83. doi: 10.1016/0006-291x(89)91066-8.

Enzymatic generation of alloxan radicals in rat liver microsomes: possible participation of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome P-450 reductase.大鼠肝微粒体中四氧嘧啶自由基的酶促生成：还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）-细胞色素P-450还原酶的可能参与。

Chem Pharm Bull (Tokyo). 1992 Feb;40(2):432-5. doi: 10.1248/cpb.40.432.

Spin trapping of alcohol-derived radicals in microsomes and reconstituted systems by electron spin resonance.

Methods Enzymol. 1994;233:117-27. doi: 10.1016/s0076-6879(94)33014-x.

Spin trapping of a free radical intermediate formed during microsomal metabolism of hydrazine.肼微粒体代谢过程中形成的自由基中间体的自旋捕获。

Biochem Biophys Res Commun. 1985 Dec 31;133(3):1086-91. doi: 10.1016/0006-291x(85)91247-1.

[Substrate reduction and oxygen activation during microsomal metabolism of quinones].[醌类微粒体代谢过程中的底物还原与氧激活]

Biokhimiia. 1987 Nov;52(11):1898-906.

Microsomal reduction of bisulfite (aqueous sulfur dioxide)--sulfur dioxide anion free radical formation by cytochrome P-450.微粒体对亚硫酸氢盐（水合二氧化硫）的还原作用——细胞色素P-450介导形成二氧化硫阴离子自由基

Biochem Pharmacol. 1985 Aug 15;34(16):3005-8. doi: 10.1016/0006-2952(85)90032-2.

[Interactions of microsomal cytochrome P-450 with spin-labeled substrate analogs].[微粒体细胞色素P-450与自旋标记底物类似物的相互作用]

Biokhimiia. 1983 Jun;48(6):897-905.

Reduction of alloxan by microsomal electron transport proteins.微粒体电子传递蛋白对四氧嘧啶的还原作用。

Biochem Biophys Res Commun. 1983 Jul 29;114(2):578-83. doi: 10.1016/0006-291x(83)90819-7.

[Interrelation of the processes of lipid peroxidation and hydroxylation in the liver microsomal fraction of white rats with alloxan diabetes].

Vopr Med Khim. 1985 Mar-Apr;31(2):62-4.

本文引用的文献

Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。

J Biol Chem. 1951 Nov;193(1):265-75.

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.肝微粒体的一氧化碳结合色素。I. 其血红蛋白性质的证据。

J Biol Chem. 1964 Jul;239:2370-8.

Inhibition of alloxan action in isolated pancreatic islets by superoxide dismutase, catalase, and a metal chelator.超氧化物歧化酶、过氧化氢酶和金属螯合剂对分离的胰岛中四氧嘧啶作用的抑制

Diabetes. 1980 Mar;29(3):213-6. doi: 10.2337/diab.29.3.213.

Superoxide radical: an endogenous toxicant.超氧阴离子自由基：一种内源性毒物。

Annu Rev Pharmacol Toxicol. 1983;23:239-57. doi: 10.1146/annurev.pa.23.040183.001323.

The effect of pH on the conversion of superoxide to hydroxyl free radicals.

Arch Biochem Biophys. 1984 Oct;234(1):258-64. doi: 10.1016/0003-9861(84)90348-5.

Monolayer cell culture of neonatal rat pancreas: light microscopy and evidence for immunoreactive insulin synthesis and release.新生大鼠胰腺的单层细胞培养：光学显微镜检查及免疫反应性胰岛素合成与释放的证据。

Endocrinology. 1972 Jan;90(1):239-48. doi: 10.1210/endo-90-1-239.

Prevention of alloxan-induced diabetes by ethanol administration.通过给予乙醇预防四氧嘧啶诱导的糖尿病。

J Pharmacol Exp Ther. 1974 Sep;190(3):501-6.

The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.6-羟基多巴胺、二羟基尿酸及相关细胞毒性剂产生过氧化氢、超氧阴离子自由基和羟基自由基的过程。

J Biol Chem. 1974 Apr 25;249(8):2447-52.

Alloxan: history and mechanism of action.四氧嘧啶：历史与作用机制

Diabetologia. 1988 Jun;31(6):337-42. doi: 10.1007/BF02341500.

Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro.超氧化物歧化酶、过氧化氢酶和羟自由基清除剂可在体外保护胰岛细胞免受四氧嘧啶的毒性作用。

Biochem J. 1979 Jul 15;182(1):17-25. doi: 10.1042/bj1820017.

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