1] Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel. [2] Edmond and Lily Safra Center for Brain Research, Hebrew University, Jerusalem 91904, Israel.
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
Nat Rev Neurosci. 2015 Feb;16(2):94-108. doi: 10.1038/nrn3888.
Spatial orientation and navigation rely on the acquisition of several types of sensory information. This information is then transformed into a neural code for space in the hippocampal formation through the activity of place cells, grid cells and head-direction cells. These spatial representations, in turn, are thought to guide long-range navigation. But how the representations encoded by these different cell types are integrated in the brain to form a neural 'map and compass' is largely unknown. Here, we discuss this problem in the context of spatial navigation by bats and rats. We review the experimental findings and theoretical models that provide insight into the mechanisms that link sensory systems to spatial representations and to large-scale natural navigation.
空间定位和导航依赖于几种类型的感觉信息的获取。然后，通过位置细胞、网格细胞和头部方向细胞的活动，这些信息被转化为海马结构中的空间神经编码。反过来，这些空间表示被认为指导长距离导航。但是，不同类型的细胞编码的表示如何在大脑中整合形成神经“地图和指南针”，在很大程度上是未知的。在这里，我们在蝙蝠和老鼠的空间导航背景下讨论这个问题。我们回顾了实验结果和理论模型，这些结果和模型为理解将感觉系统与空间表示和大规模自然导航联系起来的机制提供了深入的见解。
