[肿瘤微环境——肿瘤转移的关键要素]
[Tumor microenvironment--the critical element of tumor metastasis].
作者信息
Yang Fang, Yu Yan
机构信息
Department of Medical Oncology, Tumor Hospital, Harbin Medical University, Harbin 150081, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2015 Jan;18(1):48-54. doi: 10.3779/j.issn.1009-3419.2015.01.08.
Abstract
Metastasis is the main reason for the failure of cancer therapy and the death of patients. The molecular mechanism is complex, involving the change of multi-step, multi-stage and multi-gene. As the survival places of tumor cells, the tumor microenvironment plays a crucial role in tumor metastasis. Therefore, the study of the dynamic relationship between the tumor microenvironment and tumor metastasis, to clarify the molecular mechanisms in the metastasis process is the key point to inhibit the tumor metastasis.
摘要
转移是癌症治疗失败和患者死亡的主要原因。其分子机制复杂，涉及多步骤、多阶段和多基因的变化。肿瘤微环境作为肿瘤细胞的生存场所，在肿瘤转移中起着至关重要的作用。因此，研究肿瘤微环境与肿瘤转移之间的动态关系，阐明转移过程中的分子机制是抑制肿瘤转移的关键。
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