Armando Cortés, Bravo Luis Eduardo, Clín Pat, García Luz Stella, Collazos Paola
Departamento de Patología, Facultad de Salud, Universidad del Valle, Cali, Valle del Cauca, Colombia.
Registro Poblacional de Cáncer de Cali, Facultad de Salud, Universidad del Valle, Cali, Valle del Cauca, Colombia.
Salud Publica Mex. 2014 Sep-Oct;56(5):457-64.
To study the colorectal cancer (CRC) behavior in Cali, Colombia, during the 1963-2012 period using data from the Population-based Cancer Registry of Cali and the Municipal Health Secretariat of Cali.
An ecological time series analysis to study the CRC incidence (1962-2007) and mortality (1984-2012) rate trends; and a survival analysis of CRC cases registered in Cali between 1995 and 2004 were conducted. The age-standardized temporal trend of incidence (I-ASR) and mortality (M-ASR) rates were studied using an annual percent change (APC). The 5-year relative survival was estimated and a multivariate analysis was performed using the Cox proportional hazard regression model.
During the 1962-2007 period, CRC TTIR increased in men and women living in Cali [APC= 2.6 (95% CI 2.2-3.0) and APC= 2.2% (95% CI 1.8-2.7), respectively]. In the 1984-2012 period, the TTMR remained stable in women but increased in men in all age groups [APC= 1.8 (95% CI 0.8-2.8)]. The 5-year relative survival was independent of sex and increased from 29.7% in 1995-1999 to 39.8% in 2000-2004. The risk of dying from CRC was higher in people of lower socio-economic status (SES) vs higher SES [HR= 2.1 (95% CI: 1.7-2.6)], among people older than 70 years of age vs younger than 50 years [HR= 2.4 (95% CI: 1.9-2.9)], and for the 1995-1999 period vs 2000-2004 period [HR= 1.5 (95% CI 1.3-1.7)].
CRC is beginning to take a prominent place among the most important cancers in Cali, Colombia.
利用来自卡利市基于人群的癌症登记处和卡利市卫生秘书处的数据，研究1963 - 2012年期间哥伦比亚卡利市的结直肠癌（CRC）发病情况。
进行生态时间序列分析以研究CRC发病率（1962 - 2007年）和死亡率（1984 - 2012年）趋势；并对1995年至2004年在卡利市登记的CRC病例进行生存分析。使用年度百分比变化（APC）研究发病率（I - ASR）和死亡率（M - ASR）的年龄标准化时间趋势。估计5年相对生存率，并使用Cox比例风险回归模型进行多变量分析。
在1962 - 2007年期间，居住在卡利市的男性和女性的CRC总发病率上升[APC分别为2.6（95%CI 2.2 - 3.0）和2.2%（95%CI 1.8 - 2.7）]。在1984 - 2012年期间，女性的总死亡率保持稳定，但所有年龄组的男性死亡率均上升[APC = 1.8（95%CI 0.8 - 2.8）]。5年相对生存率与性别无关，从1995 - 1999年的29.7%上升至2000 - 2004年的39.8%。社会经济地位较低（SES）人群死于CRC的风险高于社会经济地位较高人群[HR = 2.1（95%CI：1.7 - 2.6）]，70岁以上人群高于50岁以下人群[HR = 2.4（95%CI：1.9 - 2.9）]，1995 - 1999年期间高于2000 - 2004年期间[HR = 1.5（95%CI 1.3 - 1.7）]。
在哥伦比亚卡利市，结直肠癌开始在最重要的癌症中占据显著地位。
