Palmer Biff F
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA,
Curr Hypertens Rep. 2015 Jan;17(1):510. doi: 10.1007/s11906-014-0510-4.
Arginine vasopressin (AVP) is the principal hormone involved in regulating the tonicity of body fluids. Less appreciated is the role that AVP plays in a variety of other physiologic functions including glucose metabolism, cardiovascular homeostasis, bone metabolism, and cognitive behavior. AVP receptor antagonists are now available and currently approved to treat hyponatremia. There is a great deal of interest in exploring the potential benefits that these drugs may play in blocking AVP-mediated effects in other organ systems. The purpose of this report is to provide an update on the expanding role of AVP receptor antagonists and what disease states these drugs may eventually be used for.
精氨酸加压素（AVP）是参与调节体液渗透压的主要激素。AVP在多种其他生理功能中所起的作用却鲜为人知，这些功能包括葡萄糖代谢、心血管稳态、骨代谢和认知行为。目前已有AVP受体拮抗剂，并且已获批准用于治疗低钠血症。人们对探索这些药物在阻断其他器官系统中AVP介导的效应方面可能发挥的潜在益处有着浓厚兴趣。本报告的目的是提供关于AVP受体拮抗剂不断扩展的作用以及这些药物最终可能用于哪些疾病状态的最新信息。
