输血传播登革热的实时症状病例。
Real-time symptomatic case of transfusion-transmitted dengue.
作者信息
Levi José Eduardo, Nishiya Anna, Félix Alvina Clara, Salles Nanci Alves, Sampaio Luciana Ribeiro, Hangai Fátima, Sabino Ester Cerdeira, Mendrone Alfredo
机构信息
Fundação Pró-Sangue, Hemocentro de São Paulo, University of São Paulo, São Paulo, Brazil.
Virology Lab, Instituto de Medicina Tropical da Universidade de São Paulo, University of São Paulo, São Paulo, Brazil.
出版信息
Transfusion. 2015 May;55(5):961-4. doi: 10.1111/trf.12944. Epub 2015 Jan 21.
BACKGROUND
Dengue virus transmission by blood transfusion is a rarely reported event.
CASE REPORT
During a dengue outbreak in São Paulo city, a regular plateletpheresis donor informed the blood bank of being diagnosed a few days after donation. The recipient was hospitalized and displayed symptoms and laboratory evidence of dengue after transfusion.
RESULTS
The donor was immunoglobulin (Ig)G, IgM, and polymerase chain reaction nonreactive on the index sample, seroconverting 20 days later. The platelet units were transfused into two patients. One of them developed fever 3 days after transfusion, with high viral load. His pretransfusion sample was negative for IgG, IgM, and dengue RNA, while the second recipient did not show any symptoms nor laboratory evidence of dengue infection.
CONCLUSIONS
This case brings additional evidence that dengue is indeed transmissible by blood transfusion and clinical manifestations, although rare, do occur.
背景
通过输血传播登革病毒是一个鲜有报道的事件。
病例报告
在圣保罗市登革热疫情期间，一名定期进行血小板单采术的献血者在献血几天后告知血库其被诊断感染。受血者住院并在输血后出现登革热症状及实验室证据。
结果
献血者在初次样本中免疫球蛋白（Ig）G、IgM及聚合酶链反应均为阴性，20天后血清转化。血小板单位输给了两名患者。其中一名患者在输血3天后出现发热，病毒载量高。其输血前样本的IgG、IgM及登革热RNA均为阴性，而第二名受血者未出现任何登革热感染的症状或实验室证据。
结论
该病例进一步证明登革热确实可通过输血传播，且临床表现虽罕见，但确实会发生。
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