巴西中西部地区登革热流行期间无症状献血者的血清流行率。
Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil.
机构信息
Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
出版信息
PLoS One. 2019 Mar 25;14(3):e0213793. doi: 10.1371/journal.pone.0213793. eCollection 2019.
Dengue virus (DENV) transmission by blood transfusion is an important route of viral acquisition during outbreaks. The prevalence of DENV markers (viral RNA, NS1, anti-DENV IgM, and IgG) among blood donors in Central-West Brazil has never been evaluated. Our aim was to evaluate the full set of serological and molecular markers for DENV among blood donors of the Federal District of Brazil during an extensive outbreak in 2016. We found an anti-DENV IgM prevalence of 6.74% (n = 32/475). Of 475, 20 samples (4.21%) were also anti-DENV IgG positive. All samples were non-reactive for NS1 and DENV RNA. Our results imply that a significant proportion of the tested donors had experienced asymptomatic infection. More studies are necessary to evaluate the real prevalence of DENV viremia in blood donors from the Federal District of Brazil and if specific measures are needed to routinely test the blood donors for DENV RNA during outbreaks.
登革热病毒（DENV）通过输血传播是疫情期间病毒获得的重要途径。巴西中西部献血者中登革热病毒标志物（病毒 RNA、NS1、抗登革热 IgM 和 IgG）的流行情况从未得到评估。我们的目的是在 2016 年广泛暴发期间评估巴西联邦区献血者的全套血清学和分子登革热病毒标志物。我们发现抗登革热 IgM 的流行率为 6.74%（n=475，32/32）。在 475 例中，有 20 例（4.21%）也为抗登革热 IgG 阳性。所有样本对 NS1 和 DENV RNA 均无反应。我们的结果表明，相当一部分检测到的献血者曾经历过无症状感染。需要进行更多的研究来评估巴西联邦区献血者中登革热病毒血症的真实流行率，以及在疫情期间是否需要对献血者常规检测 DENV RNA。
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