我们过去的未来：用于骨科组织工程的脐带。
A future in our past: the umbilical cord for orthopaedic tissue engineering.
作者信息
Marmotti Antonio, Peretti Giuseppe Maria, Mattia Silvia, Bonasia Davide Edoardo, Bruzzone Matteo, Dettoni Federico, Rossi Roberto, Castoldi Filippo
机构信息
University of Turin, Department of Orthopaedics and Traumatology, Turin, Italy.
Department of Biomedical Sciences for Health, University of Milan, Milan, Italy, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
出版信息
Joints. 2014 May 8;2(1):20-5. eCollection 2014 Jan-Mar.
The umbilical cord (UC) has recently been added to the list of potential cell sources for tissue engineering and regenerative medicine purposes. Although the UC is usually discarded after delivery, UC storage in special tissue banks is becoming an increasingly common procedure. Indeed, the capacity of UC cells to be directed toward different phenotypes makes this tissue an ideal cell source for regenerative medicine in orthopedics and in other fields. In this paper, these issues are presented and discussed, together with the potential of this cell source for allogeneic use. This article also looks at the anatomy of the UC from both the macroscopic and the cellular perspective and considers its extraordinary potential for research and clinical applications.
脐带最近已被列入用于组织工程和再生医学目的的潜在细胞来源清单。尽管脐带通常在分娩后被丢弃，但在特殊组织库中储存脐带正变得越来越普遍。事实上，脐带细胞定向分化为不同表型的能力使这种组织成为骨科及其他领域再生医学的理想细胞来源。本文将介绍并讨论这些问题，以及这种细胞来源用于同种异体用途的潜力。本文还将从宏观和细胞层面审视脐带的解剖结构，并探讨其在研究和临床应用方面的巨大潜力。
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