Lochmüller H, Stucka R, Feldmann H
Institut für Physiologische Chemie, Universität München, Federal Republic of Germany.
Curr Genet. 1989 Oct;16(4):247-52. doi: 10.1007/BF00422110.
Ty4 is a novel transposable element in the yeast, Saccharomyces cerevisiae, which is present in only a few copies in the genome (Stucka et al. 1989). In strain C836 one of the three copies (Ty4-90) is contained in cosmid clone c90, where it resides on chromosome V. Analysis of this region reveals a "hot-spot" of transposition: in addition to Ty4-90, the locus contains a complete Ty3 element and seven singular delta, sigma and tau elements. Three tRNA genes (for His, Lys, and Ile) are located in this region, and these are closely associated with one or the other of the elements, a phenomenon commonly observed in yeast. A comparison of c90 with corresponding regions from other strains shows that the locus is highly polymorphic and that this polymorphism is explicitly associated with Ty transposition and recombination events.
Ty4是酵母酿酒酵母中的一种新型转座元件，在基因组中仅存在少数几个拷贝（Stucka等人，1989年）。在C836菌株中，三个拷贝之一（Ty4-90）包含在黏粒克隆c90中，它位于第五条染色体上。对该区域的分析揭示了一个转座“热点”：除了Ty4-90之外，该位点还包含一个完整的Ty3元件以及七个单个的δ、σ和τ元件。三个tRNA基因（用于组氨酸、赖氨酸和异亮氨酸）位于该区域，并且它们与其中一个或另一个元件紧密相关，这是酵母中常见的现象。将c90与其他菌株的相应区域进行比较表明，该位点具有高度多态性，并且这种多态性与Ty转座和重组事件明确相关。
