2型（非胰岛素依赖型）糖尿病合并慢性肾小球肾炎患者的血清血管紧张素转换酶活性
Serum angiotensin converting enzyme activity in type 2 (non-insulin-dependent) diabetic patients with chronic glomerulonephritis.
作者信息
Ninomiya Y, Arakawa M
机构信息
Department of Medicine (II), Niigata University School of Medicine, Japan.
出版信息
Diabetes Res. 1989 Jul;11(3):121-4.
To determine the value of measuring serum angiotensin converting enzyme (ACE) activity in type 2 (non-insulin-dependent) diabetic patients who have proteinuria, 19 diabetic patients with chronic glomerulonephritis (CGN), 20 diabetic patients with diabetic glomerulosclerosis and 20 healthy controls were studied. Serum ACE activity was significantly (p less than 0.01) higher in patients with diabetic glomerulosclerosis (26.7 +/- 4.9), while in patients with CGN it was comparable to that in healthy controls (21.5 +/- 3.5, 19.1 +/- 4.7, respectively). These results suggest that measurement of serum ACE activity may be useful in differentiating between diabetic glomerulosclerosis and CGN in type 2 diabetic patients who have proteinuria.
为了确定在有蛋白尿的2型（非胰岛素依赖型）糖尿病患者中测量血清血管紧张素转换酶（ACE）活性的价值，对19例患有慢性肾小球肾炎（CGN）的糖尿病患者、20例患有糖尿病肾小球硬化症的糖尿病患者和20名健康对照者进行了研究。糖尿病肾小球硬化症患者的血清ACE活性显著（p<0.01）升高（26.7±4.9），而CGN患者的血清ACE活性与健康对照者相当（分别为21.5±3.5和19.1±4.7）。这些结果表明，测量血清ACE活性可能有助于鉴别有蛋白尿的2型糖尿病患者的糖尿病肾小球硬化症和CGN。
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